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PD-L1 expression in papillary thyroid cancer with and without lymphocytic thyroiditis: a cross sectional study


Fadia, M and Fookeerah, P and Ali, S and Shadbolt, B and Greenaway, TM and Perampalam, S, PD-L1 expression in papillary thyroid cancer with and without lymphocytic thyroiditis: a cross sectional study, Pathology, 52, (3) pp. 318-322. ISSN 0031-3025 (2020) [Refereed Article]

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Crown Copyright 2020 Published by Elsevier B.V. on behalf of Royal College of Pathologists of Australasia. All rights reserved.

DOI: doi:10.1016/j.pathol.2019.11.007


The impact of concurrent autoimmune thyroid disease on the tumour microenvironment and disease progression in papillary thyroid cancer (PTC) is not well understood. Studies evaluating the programmed cell death ligand 1 (PD-L1) tumour expression in PTC have shown variable results, and the effect of lymphocytic thyroiditis (LT) on tumour PD-L1 expression has not been adequately assessed. The main aim of this study was to determine expression of PD-L1 in PTC with and without LT. We examined 81 PTC cases; 28.5% of all reviewed PTC had presence of LT. In PTC specimens without LT, tumour PD-L1 expression was significantly lower compared to PD-L1 expression in PTC with LT, 6.9% vs 39.1%, respectively. Expression of PD-L1 did not differ with PTC stage, even when sub-categorised according to the presence and absence of LT. Utility of PD- L1 expression as a prognostic marker in thyroid cancer needs to be interpreted with caution.

Item Details

Item Type:Refereed Article
Keywords:PD-L, Papillary thyroid cancer, lymphocytic thyroiditis, programmed cell death ligand 1, tumour microenvironment
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Pain
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Greenaway, TM (Dr Tim Greenaway)
ID Code:152366
Year Published:2020
Web of Science® Times Cited:7
Deposited By:Medicine
Deposited On:2022-08-18
Last Modified:2022-11-25

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