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Stable encoding of visual cues in the mouse retrosplenial cortex


Powell, A and Connelly, WM and Vasalauskaite, A and Nelson, AJD and Vann, SD and Aggleton, JP and Sengpiel, F and Ranson, A, Stable encoding of visual cues in the mouse retrosplenial cortex, Cerebral Cortex, 30, (8) pp. 4424-4437. ISSN 1047-3211 (2020) [Refereed Article]

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DOI: doi:10.1093/cercor/bhaa030


Abstract: The rodent retrosplenial cortex (RSC) functions as an integrative hub for sensory and motor signals, serving roles in both navigation and memory. While RSC is reciprocally connected with the sensory cortex, the form in which sensory information is represented in the RSC and how it interacts with motor feedback is unclear and likely to be critical to computations involved in navigation such as path integration. Here, we used 2-photon cellular imaging of neural activity of putative excitatory (CaMKII expressing) and inhibitory (parvalbumin expressing) neurons to measure visual and locomotion evoked activity in RSC and compare it to primary visual cortex (V1). We observed stimulus position and orientation tuning, and a retinotopic organization. Locomotion modulation of activity of single neurons, both in darkness and light, was more pronounced in RSC than V1, and while locomotion modulation was strongest in RSC parvalbumin-positive neurons, visual-locomotion integration was found to be more supralinear in CaMKII neurons. Longitudinal measurements showed that response properties were stably maintained over many weeks. These data provide evidence for stable representations of visual cues in RSC that are spatially selective. These may provide sensory data to contribute to the formation of memories of spatial information.

Item Details

Item Type:Refereed Article
Keywords:behavior, navigation, retrosplenial cortex, vision.
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Connelly, WM (Dr William Connelly)
ID Code:152350
Year Published:2020
Web of Science® Times Cited:16
Deposited By:Medicine
Deposited On:2022-08-17
Last Modified:2022-08-23

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