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Rationale and protocol for the 7- And 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study


Lee, SSY and Lingham, G and Yazar, S and Sanfilippo, PG and Charng, J and Chen, FK and Hewitt, AW and Ng, F and Hammond, C and Straker, LM and Eastwood, PR and MacGregor, S and Rose, KA and Lucas, RM and Guggenheim, JA and Saw, SM and Coroneo, MT and He, M and MacKey, DA, Rationale and protocol for the 7- And 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study, BMJ Open, 10, (3) pp. 1-10. ISSN 2044-6055 (2020) [Refereed Article]

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2020 Author(s). Licensed under Creative Commons Attribution Non Commercial license (CC BY-NC 4.0)

DOI: doi:10.1136/bmjopen-2019-033440


Introduction: Eye diseases and visual impairment more commonly affect elderly adults, thus, the majority of ophthalmic cohort studies have focused on older adults. Cohort studies on the ocular health of younger adults, on the other hand, have been few. The Raine Study is a longitudinal study that has been following a cohort since their birth in 1989-1991. As part of the 20-year follow-up of the Raine Study, participants underwent a comprehensive eye examination. As part of the 27- and 28-year follow-ups, eye assessments are being conducted and the data collected will be compared with those of the 20-year follow-up. This will provide an estimate of population incidence and updated prevalence of ocular conditions such as myopia and keratoconus, as well as longitudinal change in ocular parameters in young Australian adults. Additionally, the data will allow exploration of the environmental, health and genetic factors underlying inter-subject differential long-term ocular changes.

Methods and analysis: Participants are being contacted via telephone, email and/or social media and invited to participate in the eye examination. At the 27-year follow-up, participants completed a follow-up eye screening, which assessed visual acuity, autorefraction, ocular biometry and ocular sun exposure. Currently, at the 28-year follow-up, a comprehensive eye examination is being conducted which, in addition to all the eye tests performed at the 27-year follow-up visit, includes tonometry, optical coherence tomography, funduscopy and anterior segment topography, among others. Outcome measures include the incidence of refractive error and pterygium, an updated prevalence of these conditions, and the 8-year change in ocular parameters.

Item Details

Item Type:Refereed Article
Keywords:Raine Study, cohort study, myopia, ocular measures, young adults
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
ID Code:152305
Year Published:2020
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-17
Last Modified:2023-01-12
Downloads:6 View Download Statistics

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