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Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches

Citation

Dua, K and Rapalli, VK and Shukla, SD and Singhvi, G and Shastri, MD and Chellappan, DK and Satija, S and Mehta, M and Gulati, M and Pinto, TDJA and Gupta, G and Hansbro, PM, Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches, Biomedicine and Pharmacotherapy, 107 pp. 1218-1229. ISSN 0753-3322 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Elsevier Masson SAS.

DOI: doi:10.1016/j.biopha.2018.08.101

Abstract

Tuberculosis (caused by Mycobacterium tuberculosis, Mtb) treatment involves multiple drug regimens for a prolonged period. However, the therapeutic benefit is often limited by poor patient compliance, subsequently leading to treatment failure and development of antibiotic resistance. Notably, oxidative stress is a crucial underlying factor that adversely influences the various treatment regimens in tuberculosis. Little information is available with advanced drug delivery systems that could be effectively utilized, in particular, for targeting the oxidative stress in tuberculosis. Thus, this presents an opportunity to review the utility of various available, controlled-release drug delivery systems (e.g., microspheres, liposomes, niosomes, solid lipid nanoparticles, dendrimers) that could be beneficial in tuberculosis treatments. This will help the biological and formulation scientists to pave a new path in formulating a treatment regimen for multi-drug resistant Mtb.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Shastri, MD (Mr Madhur Shastri)
ID Code:152134
Year Published:2018
Web of Science® Times Cited:46
Deposited By:Plant Science
Deposited On:2022-08-11
Last Modified:2022-09-16
Downloads:0

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