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Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
Citation
Bryazka, D and Reitsma, MB and Griswold, MG and Abate, KH and Abbafati, C and Obamiro, KO, GBD 2020 Alcohol Collaborators, Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020, The Lancet, 400, (10347) pp. 185-235. ISSN 0140-6736 (2022) [Refereed Article]
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Copyright Statement
Copyright (2022) The Author(s). Published by Elsevier Ltd. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
DOI: doi:10.1016/S0140-6736(22)00847-9
Abstract
Background
The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year.
Methods
For this analysis, we constructed burden-weighted doseresponse relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 for 21 regions, including 204 countries and territories, by 5-year age group, sex, and year for individuals aged 1595 years and older from 1990 to 2020. Based on the NDE, we quantified the population consuming harmful amounts of alcohol.
Findings
The burden-weighted relative risk curves for alcohol use varied by region and age. Among individuals aged 1539 years in 2020, the TMREL varied between 0 (95% uncertainty interval 00) and 0·603 (0·4001·00) standard drinks per day, and the NDE varied between 0·002 (00) and 1·75 (0·6984·30) standard drinks per day. Among individuals aged 40 years and older, the burden-weighted relative risk curve was J-shaped for all regions, with a 2020 TMREL that ranged from 0·114 (00·403) to 1·87 (0·5003·30) standard drinks per day and an NDE that ranged between 0·193 (00·900) and 6·94 (3·408·30) standard drinks per day. Among individuals consuming harmful amounts of alcohol in 2020, 59·1% (54·365·4) were aged 1539 years and 76·9% (73·081·3) were male.
Interpretation
There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | alcohol, disease burden, consumption |
| Research Division: | Health Sciences |
| Research Group: | Health services and systems |
| Research Field: | Rural and remote health services |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Nutrition |
| UTAS Author: | Obamiro, KO (Dr Kehinde Obamiro) |
| ID Code: | 151909 |
| Year Published: | 2022 |
| Web of Science® Times Cited: | 18 |
| Deposited By: | UTAS Centre for Rural Health |
| Deposited On: | 2022-08-08 |
| Last Modified: | 2022-12-10 |
| Downloads: | 2 View Download Statistics |
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