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The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

Citation

Dua, K and Wadhwa, R and Singhvi, G and Rapalli, V and Shukla, SD and Shastri, MD and Gupta, G and Satija, S and Mehta, M and Khurana, N and Awasthi, R and Maurya, PK and Thangavelu, L and Rajeshkumar, S and Tambuwala, MM and Collet, T and Hansbro, PM and Chellappan, DK, The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress, Drug Development Research, 80, (6) pp. 714-730. ISSN 0272-4391 (2019) [Refereed Article]


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DOI: doi:10.1002/ddr.21571

Abstract

Lung diseases are the leading cause of mortality worldwide. The currently available therapies are not sufficient, leading to the urgent need for new therapies with sustained anti-inflammatory effects. Small/short or silencing interfering RNA (siRNA) has potential therapeutic implications through post-transcriptional downregulation of the target gene expression. siRNA is essential in gene regulation, so is more favorable over other gene therapies due to its small size, high specificity, potency, and no or low immune response. In chronic respiratory diseases, local and targeted delivery of siRNA is achieved via inhalation. The effectual delivery can be attained by the generation of aerosols via inhalers and nebulizers, which overcomes anatomical barriers, alveolar macrophage clearance and mucociliary clearance. In this review, we discuss the different siRNA nanocarrier systems for chronic respiratory diseases, for safe and effective delivery. siRNA mediated pro-inflammatory gene or miRNA targeting approach can be a useful approach in combating chronic respiratory inflammatory conditions and thus providing sustained drug delivery, reduced therapeutic dose, and improved patient compliance. This review will be of high relevance to the formulation, biological and translational scientists working in the area of respiratory diseases.

Item Details

Item Type:Refereed Article
Keywords:RNA interference, delivery systems, nanocarriers, pulmonary, siRNA
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical delivery technologies
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Shastri, MD (Mr Madhur Shastri)
ID Code:151819
Year Published:2019
Web of Science® Times Cited:80
Deposited By:Health Sciences
Deposited On:2022-08-05
Last Modified:2022-08-05
Downloads:0

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