eCite Digital Repository

Recent advances in open tubular capillary liquid chromatography


Lam, SC and Sanz Rodriguez, E and Haddad, PR and Paull, B, Recent advances in open tubular capillary liquid chromatography, Analyst, 144, (11) pp. 3464-3482. ISSN 0003-2654 (2019) [Refereed Article]

Copyright Statement

The Royal Society of Chemistry 2019

DOI: doi:10.1039/c9an00329k


This review covers advances and applications of open tubular capillary liquid chromatography (OT-LC) over the period 2007-2018. Under the right conditions OT-LC columns have the potential to offer superior column efficiency, higher overall peak capacity, and higher column permeability compared to packed capillary and monolithic columns. However, such advantages are highly dependent upon column format and dimensions, and to date in liquid chromatography the advantages of open tubular format columns have been most widely discussed and applied in the field of proteomics. In this review we have focused on the wider variety of separation mechanisms and applications which can be achieved following the modification of the inner wall of the capillary with a thin-layer stationary phase. In particular the latest advances in stationary phase development and formation, together with new column formats and dimensions are reviewed. Detection options for OT-LC are also discussed and recent advances in this area highlighted. Finally, this review summarises existing applications of OT-LC and illustrates the future potential for this technique.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Lam, SC (Mr Shing Chung Lam)
UTAS Author:Sanz Rodriguez, E (Dr Estrella Sanz Rodriguez)
UTAS Author:Haddad, PR (Professor Paul Haddad)
UTAS Author:Paull, B (Professor Brett Paull)
ID Code:151799
Year Published:2019
Web of Science® Times Cited:35
Deposited By:Plant Science
Deposited On:2022-08-04
Last Modified:2022-09-01

Repository Staff Only: item control page