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Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

Citation

Dua, K and Malyla, V and Singhvi, G and Wadhwa, R and Krishna, RV and Shukla, SD and Shastri, MD and Chellappan, DK and Maurya, PK and Satija, S and Mehta, M and Gulati, M and Hansbro, N and Collet, T and Awasthi, R and Gupta, G and Hsu, A and Hansbro, PM, Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems, Chemico-Biological Interactions, 299 pp. 168-178. ISSN 0009-2797 (2019) [Refereed Article]


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DOI: doi:10.1016/j.cbi.2018.12.009

Abstract

Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic.

Item Details

Item Type:Refereed Article
Keywords:asthma, COPD, drug delivery, lung cancer, respiratory diseases
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Shastri, MD (Mr Madhur Shastri)
ID Code:151783
Year Published:2019
Web of Science® Times Cited:61
Deposited By:Health Sciences
Deposited On:2022-08-04
Last Modified:2022-08-04
Downloads:0

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