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Miniaturized LC in molecular omics


Aydogan, C and Rigano, F and Krcmova, LK and Chung, DS and Macka, M and Mondello, L, Miniaturized LC in molecular omics, Analytical Chemistry, 92, (17) pp. 11485-11497. ISSN 0003-2700 (2020) [Refereed Article]

DOI: doi:10.1021/acs.analchem.0c01436


Miniaturized LC has evolved at an exponential rate over the last 50 years. In the past decade, it has received considerable attention in the field of bioanalytical separation science and technology due to the need to measure different classes of biomolecules present in a variety of matrixes on a global scale to gain a deeper understanding of complex biological processes. This field has become a dominant area underpinning the molecular omics research (e.g., proteomics, metabolomics, lipidomics, and foodomics), allowing key insights into the function and mechanism of small to very large biomolecules on a molecular level. This Feature highlights the recent advances in molecular omics focusing on miniaturized LC technology combined with mass spectrometry-based platforms, with a particular emphasis on the strategies adopted and applications using new and sensitive nanoscale analytical methodologies.

Item Details

Item Type:Refereed Article
Keywords:chromatography, metabolism, metabolomics, peptides and proteins, proteomics
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - amino acids and metabolites
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Macka, M (Professor Mirek Macka)
ID Code:151690
Year Published:2020
Web of Science® Times Cited:20
Deposited By:Chemistry
Deposited On:2022-08-03
Last Modified:2022-08-23

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