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Association of urinary or blood heavy metals and mortality from all causes, cardiovascular disease, and cancer in the general population: a systematic review and meta‑analysis of cohort studies

Citation

Guo, X and Su, W and Li, N and Song, Q and Wang, H and Liang, Q and Li, Y and Lowe, S and Bentley, R and Zhou, Z and Song, EJ and Cheng, C and Zhou, Q and Sun, C, Association of urinary or blood heavy metals and mortality from all causes, cardiovascular disease, and cancer in the general population: a systematic review and meta‑analysis of cohort studies, Environmental Science and Pollution Research: International ISSN 0944-1344 (2022) [Refereed Article]

Copyright Statement

Copyright 2022 The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature

DOI: doi:10.1007/s11356-022-22353-w

Abstract

Amounting epidemiological evidence has shown detrimental effects of heavy metals on a wide range of diseases. However, the effect of heavy metal exposure on mortality in the general population remains unclear. The primary objective of this study was to clarify the associations between heavy metals and mortality from all causes, cardiovascular disease (CVD), and cancer based on prospective studies. We comprehensively searched Pubmed, Embase, and Web of Science electronic databases to identify studies published from their inception until 1 March 2022. Investigators identified inclusion criteria, extracted study characteristics, and assessed the methodological quality of included studies according to standardized guidelines. Meta-analysis was conducted if the effect estimates of the same outcome were reported in at least three studies. Finally, 42 original studies were identified. The results of meta-analysis showed that cadmium and lead exposure was significantly associated with mortality from all causes, CVD, and cancer in the general population. Moderate evidence suggested there was a link between arsenic exposure and mortality. The adverse effects of mercury and other heavy metals on mortality were inconclusive. Epidemiological evidence for the joint effect of heavy metal exposure on mortality was still indeterminate. In summary, our study provided compelling evidence that exposure to cadmium, lead, and arsenic were associated with mortality from all causes, CVD, and cancer, while the evidence on other heavy metals, for example mercury, was insignificant or indeterminate. Nevertheless, further prospective studies are warranted to explore the joint effects of multiple metal exposure on mortality.

Item Details

Item Type:Refereed Article
Keywords:heavy metal, meta-analysis, mortality, prospective studies
Research Division:Environmental Sciences
Research Group:Pollution and contamination
Research Field:Pollution and contamination not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Zhou, Z (Dr Zhen Zhou)
ID Code:151680
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-03
Last Modified:2022-09-02
Downloads:0

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