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Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases

Citation

Schwartz, MD and Canales, JJ and Zucchi, R and Espinoza, S and Sukhanov, I and Gainetdinov, RR, Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases, Expert Opinion on Therapeutic Targets, 22, (6) pp. 513-526. ISSN 1472-8222 (2018) [Refereed Article]


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DOI: doi:10.1080/14728222.2018.1480723

Abstract

The trace amines, endogenous amines closely related to the biogenic amine neurotransmitters, have been known to exert physiological and neurological effects for decades. The recent identification of a trace amine-sensitive G protein-coupled receptor, trace amine-associated receptor 1 (TAAR1), and subsequent development of TAAR1-selective small-molecule ligands, has renewed research into the therapeutic possibilities of trace amine signaling. Areas covered: Recent efforts in elucidating the neuropharmacology of TAAR1, particularly in neuropsychiatric and neurodegenerative disease, addiction, and regulation of arousal state, will be discussed. Focused application of TAAR1 mutants, synthetic TAAR1 ligands, and endogenous biomolecules such as 3-iodothyronamine (T1AM) has yielded a basic functional portrait for TAAR1, despite a complex biochemistry and pharmacology. The close functional relationship between TAAR1 and dopaminergic signaling is likely to underlie many of its CNS effects. However, TAAR1's influences on serotonin and glutamate neurotransmission will also be highlighted. Expert opinion: TAAR1 holds great promise as a therapeutic target for mental illness, addiction, and sleep disorders. A combination of preclinical and translationally driven studies has solidified TAAR1 as a key node in the regulation of dopaminergic signaling. Continued focus on the mechanisms underlying TAAR1's regulation of serotonin and glutamate signaling, as well as dopamine, will yield further disease-relevant insights.

Item Details

Item Type:Refereed Article
Keywords:dopamine, addiction, depression, neuropharmacology, psychostimulants, schizophrenia, serotonin, sleep
Research Division:Psychology
Research Group:Clinical and health psychology
Research Field:Clinical neuropsychology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Canales, JJ (Professor Juan Canales)
ID Code:151670
Year Published:2018
Web of Science® Times Cited:33
Deposited By:Psychology
Deposited On:2022-08-03
Last Modified:2022-08-03
Downloads:0

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