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Sex differences in total cholesterol of Vietnamese adults


Tran, NTT and Blizzard, CL and Luong, KN and Van Ngoc Truong, NL and Tran, BQ and Otahal, P and Nelson, MR and Magnussen, CG and Bui, TV and Srikanth, V and Bich, TB and Ha, ST and Phung, HN and Tran, MH and Callisaya, M and Gall, S, Sex differences in total cholesterol of Vietnamese adults, PLoS ONE, 16, (8) Article 0256589. ISSN 1932-6203 (2021) [Refereed Article]


Copyright Statement

Copyright: 2021 Tran et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.1371/journal.pone.0256589


Background: The mid-life emergence of higher levels of total cholesterol (TC) for women than for men has been observed in different Western and Asian populations. The aim of this study was to investigate whether there is evidence of this in Vietnam and, if so, whether it can be explained by ageing, by body size and fatness, or by socio-demographic characteristics and behavioural factors.

Methods: Participants (n = 14706, 50.9% females) aged 25-64 years were selected by multi-stage stratified cluster sampling from eight provinces each representing one of the eight geographical regions of Vietnam. Measurements were made using the World Health Organization STEPS protocols. Linear regression was used to assess the independent contributions of potential explanatory factors to mean levels of TC. Data were analysed using complex survey methods.

Results: Men and women had similar mean levels of body mass index (BMI), and men had modestly higher mean levels of waist circumference (WC), in each 5-year age category. The mean TC of women increased more or less continuously across the age range but with a step-up at age 50 years to reach higher concentrations on average than those of their male counterparts. The estimated step-up was not eliminated by adjustment for anthropometric indices including BMI or WC, or by adjustment for socio-demographic characteristics or behavioural factors. The estimated step-up was least for women with the greatest weight.

Conclusion: There is a marked step-up in TC at age 50 years for Vietnamese women that cannot be explained by their age, or by their body fatness or its distribution, or by their socio-demographic characteristics or behavioural factors, and which results in greater mean levels of TC for middle-aged women than for their male counterparts in Vietnam.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Behavioural epidemiology
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Behaviour and health
UTAS Author:Tran, NTT (Dr Nga Tran)
UTAS Author:Blizzard, CL (Professor Leigh Blizzard)
UTAS Author:Otahal, P (Mr Petr Otahal)
UTAS Author:Nelson, MR (Professor Mark Nelson)
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
UTAS Author:Bui, TV (Dr Tan Bui)
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
UTAS Author:Phung, HN (Dr Hai Phung)
UTAS Author:Tran, MH (Dr Mai Tran)
UTAS Author:Callisaya, M (Dr Michele Callisaya)
UTAS Author:Gall, S (Associate Professor Seana Gall)
ID Code:151606
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-02
Last Modified:2022-12-06
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