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Regression to the mean in home blood pressure: Analyses of the BP GUIDE study

Citation

Wang, N and Atkins, ER and Salam, A and Moore, MN and Sharman, JE and Rodgers, A, Regression to the mean in home blood pressure: Analyses of the BP GUIDE study, Journal of Clinical Hypertension, 22, (7) pp. 1184-1191. ISSN 1524-6175 (2020) [Refereed Article]


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DOI: doi:10.1111/jch.13933

Abstract

The aim of our study was to estimate the size of regression to the mean with home blood pressure (BP) monitoring and compare with that for office BP. Office and home BP measures were obtained from the BP GUIDE (value of central Blood Pressure for GUIDing managEment for hypertension) study, in which 286 patients had BP measured every 3 months for 12 months. Patients were categorized by 10 mm Hg strata of baseline BP, and regression to the mean measures was calculated for home and office BP. High baseline home BP readings tended to be lower on long-term follow-up, and low baseline readings tended to be higher. For example, patients in the group with mean baseline home systolic BP ≥ 150 mm Hg had a mean baseline systolic BP of 156 mm Hg, which fell to 143 mm Hg at 12 months; and patients in the group with mean baseline home systolic BP < 120 mm Hg had a mean baseline systolic BP of 113 mm Hg which rose to 120 mm Hg at 12 months. Similar patterns were seen in intervention and control groups, and for diastolic BP. The regression dilution ratio for home systolic BP and diastolic BP was 0.52 and 0.64, respectively, compared to 0.40 and 0.55 for office systolic BP and diastolic BP, respectively. Home BP is subject to regression to the mean to a similar degree as office BP. These findings have implications for the diagnosis and management of hypertension using home BP.

Item Details

Item Type:Refereed Article
Keywords:cardiovascular disease, clinical decision making, diagnostic errors, home blood pressure monitoring
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Moore, MN (Mr Myles Moore)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:151589
Year Published:2020
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-02
Last Modified:2022-08-02
Downloads:0

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