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We have had a gutful: The need for deprescribing proton pump inhibitors


Naunton, M and Peterson, GM and Deeks, LS and Young, H and Kosari, S, We have had a gutful: The need for deprescribing proton pump inhibitors, Journal of Clinical Pharmacy and Therapeutics, 43, (1) pp. 65-72. ISSN 0269-4727 (2018) [Refereed Article]

Copyright Statement

2017 John Wiley & Sons Ltd.

DOI: doi:10.1111/jcpt.12613


What is known and objective: Proton pump inhibitor (PPI) prescribing may often be inappropriate and expose patients to a risk of adverse effects, while incurring unnecessary healthcare expenditure. Our objective was to determine PPI usage in Australia since 2002 and review international studies investigating inappropriate PPI prescribing, including those that discussed interventions to address this issue.

Methods: Australian Pharmaceutical Benefits Scheme (PBS) and Repatriation Pharmaceutical Benefits Scheme (RPBS) data were analysed. A narrative literature review relevant to the objective was conducted. Time series analysis was also used to examine the trend of reported PPI appropriate use across the international studies included in this review.

Results and discussion: Proton pump inhibitor use in Australia increased between 2002 and 2010 and then gradually decreased. Estimates of the extent of inappropriate use in the international literature had a wide variation (11-84%). There appeared to be little change in the extent of appropriate PPI use reported through 34 international studies from 2000 to 2016. Interventions to address inappropriate use included patient-centred deprescribing, academic detailing, educational programmes and drug safety notifications.

What is new and Conclusion: Proton pump inhibitors continue to be overused worldwide and should be a focus for deprescribing programmes. Ongoing education and awareness campaigns for health professionals and patients, including electronic reminders at the point of prescribing, are strategies that have potential to reduce PPI use in individuals who do not have an evidence-based clinical indication for their long-term use.

Item Details

Item Type:Refereed Article
Keywords:PPI, deprescribing, gastro-oesophageal reflux, prescribing patterns, proton pump inhibitor
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:151585
Year Published:2018
Web of Science® Times Cited:31
Deposited By:Pharmacy
Deposited On:2022-08-02
Last Modified:2022-10-20

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