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Role of microvascular dysfunction in left ventricular dysfunction in type 2 diabetes mellitus


Halabi, A and Nolan, M and Potter, E and Wright, L and Asham, A and Marwick, TH, Role of microvascular dysfunction in left ventricular dysfunction in type 2 diabetes mellitus, Journal of Diabetes and Its Complications, 35, (5) pp. 1-9. ISSN 1056-8727 (2021) [Refereed Article]

Copyright Statement

2021 Elsevier Inc.

DOI: doi:10.1016/j.jdiacomp.2021.107907


Background: Although microvascular disease (mVD) has been linked to poor cardiovascular outcomes in diabetes mellitus, the contribution of mVD to diabetic cardiomyopathy (DC) is unexplored. We investigated whether LV systolic and diastolic dysfunction is associated with mVD in T2DM.

Methods: We recruited 32 asymptomatic patients with T2DM (age 71 4 years, 31% females) from a community-based population. All underwent a comprehensive echocardiogram at baseline including assessment of global longitudinal strain (GLS) and diastolic function. Adenosine stress perfusion on cardiac magnetic resonance imaging (CMR) was performed in all patients. Coronary sinus flow (CSF) was measured offline at rest and peak stress with coronary flow reserve (CFR) calculated as the ratio of global stress and rest CSF.

Results: Resting CSF was reduced in 15 (47%) compared to 4 (13%) with adenosine-stress (p = 0.023). Overall, CFR was observed to be reduced in the cohort (2.38 [IQR 2.20]). Abnormal CFR was not associated with diabetes duration of ≥10 years or poor glycaemic control. CFR was not associated with abnormal GLS (OR 1.04 [95% CI 0.49, 2.20], p = 0.93). However, a modest negative correlation was observed with e' and CFR (r = -0.49, p = 0.004).

Conclusion: This pilot study did not show correlation between subclinical systolic dysfunction and a novel MRI biomarker of microvascular disease. However, there was a weak correlation with myocardial relaxation. Confirmation of these findings in larger studies is indicated.

Item Details

Item Type:Refereed Article
Keywords:coronary flow reserve, coronary sinus flow, diabetes, microvascular disease
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Nolan, M (Mr Mark Nolan)
UTAS Author:Marwick, TH (Professor Tom Marwick)
ID Code:151581
Year Published:2021
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-08-02
Last Modified:2022-11-21

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