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Miniaturized micromachined gas chromatography with universal and selective detectors for targeted volatile compounds analysis


Gras, R and Luong, J and Shellie, RA, Miniaturized micromachined gas chromatography with universal and selective detectors for targeted volatile compounds analysis, Journal of Chromatography A, 1573 pp. 151-155. ISSN 0021-9673 (2018) [Refereed Article]

Copyright Statement

2018 Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.chroma.2018.08.064


An effective analytical strategy for targeted analysis of volatile organic compounds which combines two orthogonal separation mechanisms and multiple tunable detection in a compact transportable analytical system is introduced. This strategy uses a commercially available micromachined gas chromatograph comprising a micromachined on-board thermal conductivity detector. The chromatograph capability is enhanced by incorporating a modified diode array detector and a radio frequency modulated ion mobility spectrometry microfabricated electromechanical system. The analytical platform offers powerful detection capabilities of individual compounds and various classes of volatile organic compounds with improved provisional confirmatory capability. The transportable micromachined gas chromatograph employs field replaceable conventional capillary columns for the separation of analytes. The use of a silicon micromachined sample introduction device affords fast injection to minimize band broadening with fast chromatographic separation rendered in the order of minutes. Advantaged synergy also includes leveraging the resolving power of gas chromatography to minimize charge exchange in the ionization chamber of the differential mobility spectrometer for improved detector performance. Performance of this scalable and transportable analytical system is demonstrated with relevant volatile compounds such as acetaldehyde, acetone, carbon disulfide, benzene, and ethyl butyrate having a day-to-day variability less than 5% and with a high degree of reliability.

Item Details

Item Type:Refereed Article
Keywords:Gas chromatography, VOC, Differential mobility spectrometry, Diode array detector, Thermal conductivity detector
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Gras, R (Ms Ronda Gras)
UTAS Author:Luong, J (Mr Jim Luong)
UTAS Author:Shellie, RA (Professor Robert Shellie)
ID Code:151565
Year Published:2018
Web of Science® Times Cited:10
Deposited By:Plant Science
Deposited On:2022-08-01
Last Modified:2022-09-06

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