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Advances in Automated Piston Liquid-Liquid Microextraction Technique
Citation
Gras, R and Liu, G and Shellie, RA and Hua, Y and Luong, J, Advances in Automated Piston Liquid-Liquid Microextraction Technique, Journal of Chromatography A, 1651 Article 462330. ISSN 0021-9673 (2021) [Refereed Article]
Copyright Statement
© 2021 Elsevier B.V. All rights reserved.
DOI: doi:10.1016/j.chroma.2021.462330
Abstract
A new automated micro liquid-liquid extraction technique was successfully developed. This novel syringe-based technique capitalizes on the advantages of vigorous fluid agitation and the shearing effect of two fluids with different properties to achieve high extraction efficiency. The technique is at least 20 times faster than mechanical shaking or sonication in achieving a similar recovery even with a hydrophilic probe molecule such as 1,4-dioxane in an aqueous medium. Excellent repeatability with a relative standard deviation as low as 0.56% over a five-day test, n = 2 per day, was demonstrated with 1,4-dioxane. Other model compounds in aqueous matrices evaluated, including phenolics and extraction solvents like chloroform and hexane, showed similar performance in repeatability. An added advantage of this technique involves performing multiple extractions. Its capabilities in conducting complicated extraction steps and minimizing the use of organic solvents as low as 200 µL to achieve a preconcentration effect were demonstrated. The technique is suitable for use with emulsion-forming samples without further sample manipulation by incorporating a demulsifier such as acetone during the extraction process. The technique was found to be efficient and environmentally friendly with low solvent waste. This technique is ideal for implementation in automated high throughput and cost-effective quality assurance laboratory environments.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Liquid-liquid extraction, Mixxor, Emulsion-forming, 1,4-dioxane, demulsifier, gas chromatography |
| Research Division: | Chemical Sciences |
| Research Group: | Analytical chemistry |
| Research Field: | Separation science |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the chemical sciences |
| UTAS Author: | Gras, R (Ms Ronda Gras) |
| UTAS Author: | Shellie, RA (Professor Robert Shellie) |
| UTAS Author: | Luong, J (Mr Jim Luong) |
| ID Code: | 151564 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 1 |
| Deposited By: | Plant Science |
| Deposited On: | 2022-08-01 |
| Last Modified: | 2022-10-27 |
| Downloads: | 0 |
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