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Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community?


Idrose, NS and Tham, RCA and Lodge, CJ and Lowe, AJ and Bui, D and Perret, JL and Vicendese, D and Newbigin, EJ and Tang, MLK and Aldakheel, FM and Waidyatillake, NT and Douglass, JA and Abramson, MJ and Walters, EH and Erbas, B and Dharmage, SC, Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community?, Allergy, 76, (4) pp. 1136-1146. ISSN 0105-4538 (2020) [Refereed Article]

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DOI: doi:10.1111/all.14566


Background: The association between grass pollen exposure and early markers of asthma exacerbations such as lung function changes and increase in airway inflammation is limited. We investigated the associations between short-term grass pollen exposure and lung function and airway inflammation in a community-based sample, and whether any such associations were modified by current asthma, current hay fever, pollen sensitization, age, and other environmental factors.

Methods: Cross-sectional and short-term analyses of data from the Melbourne Atopy Cohort Study (MACS) participants (n = 936). Lung function was assessed using spirometry. Airway inflammation was assessed by fractional exhaled nitric oxide (FeNO) and exhaled breath condensate pH and nitrogen oxides (NOx). Daily pollen counts were collected using a volumetric spore trap. The associations were examined by linear regression.

Results: Higher ambient levels of grass pollen 2 days before (lag 2) were associated with lower mid-forced expiratory flow (FEF25%-75%) and FEV1/FVC ratio (Coef. [95% CI] = -119 [-226, -11] mL/s and -1.0 [-3.0, -0.03] %, respectively) and also 3 days before (lag 3). Increased levels of grass pollen a day before (lag 1) were associated with increased FeNO (4.35 [-0.1, 8.7] ppb) and also at lag 2. Adverse associations between pollen and multiple outcomes were greater in adults with current asthma, hay fever, and pollen sensitization.

Conclusion: Grass pollen exposure was associated with eosinophilic airway inflammation 1-2 days after exposure and airway obstruction 2-3 days after exposure. Adults and individuals with asthma, hay fever, and pollen sensitization may be at higher risk.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:151487
Year Published:2020
Web of Science® Times Cited:3
Deposited By:Medicine
Deposited On:2022-07-31
Last Modified:2022-07-31

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