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Molecular mechanisms of intestinal inflammation leading to colorectal cancer


Shastri, S and Vemuri, R and Guven, N and Shastri, MD and Eri, R, Molecular mechanisms of intestinal inflammation leading to colorectal cancer, AIMS Biophysics, 4, (1) pp. 152-177. ISSN 2377-9098 (2017) [Refereed Article]

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Copyright Statement

2017 Rajaraman Eri, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0 License (

DOI: doi:10.3934/biophy.2017.1.152


Inflammatory bowel disease (IBD) is recognized as a leading cause in the development of colorectal cancer (CRC). Inflammatory bowel disease associated colorectal cancer (IBD-CRC) is a growing healthcare burden, causing significant morbidity and mortality world-wide. In the present review, relevant preclinical models of IBD-CRC, a concise overview of potential molecular mechanisms that are involved and responsible for IBD associated colonic tumorigenesis along with the current and the future therapeutic approaches including the role of novel natural and synthetic compounds for the prevention and treatment of IBD-CRC are outlined. This review will benefit various clinicians and translational researchers working in the area of IBD-CRC to have a quick snap-shot of the ongoing trends in IBD-CRC research and discoveries.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Shastri, S (Mrs Sonia Shastri)
UTAS Author:Vemuri, R (Mr Ravichandra Vemuri)
UTAS Author:Guven, N (Dr Nuri Guven)
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:151485
Year Published:2017
Deposited By:Pharmacy
Deposited On:2022-07-31
Last Modified:2022-09-08
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