151485 - Molecular mechanisms of intestinal inflammation leading to colorectal cancer.pdf (711.61 kB)
Molecular mechanisms of intestinal inflammation leading to colorectal cancer
journal contribution
posted on 2023-05-21, 10:11 authored by Shastri, S, Vemuri, R, Nuri GuvenNuri Guven, Madhur ShastriMadhur Shastri, Rajaraman EriInflammatory bowel disease (IBD) is recognized as a leading cause in the development of colorectal cancer (CRC). Inflammatory bowel disease associated colorectal cancer (IBD-CRC) is a growing healthcare burden, causing significant morbidity and mortality world-wide. In the present review, relevant preclinical models of IBD-CRC, a concise overview of potential molecular mechanisms that are involved and responsible for IBD associated colonic tumorigenesis along with the current and the future therapeutic approaches including the role of novel natural and synthetic compounds for the prevention and treatment of IBD-CRC are outlined. This review will benefit various clinicians and translational researchers working in the area of IBD-CRC to have a quick snap-shot of the ongoing trends in IBD-CRC research and discoveries.
History
Publication title
AIMS BiophysicsVolume
4Pagination
152-177ISSN
2377-9098Department/School
School of Health SciencesPublisher
AIMS PressPlace of publication
United StatesRights statement
© 2017 Rajaraman Eri, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0 License (http://creativecommons.org/licenses/by/4.0)Repository Status
- Open