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Molecular mechanisms of intestinal inflammation leading to colorectal cancer
Citation
Shastri, S and Vemuri, R and Guven, N and Shastri, MD and Eri, R, Molecular mechanisms of intestinal inflammation leading to colorectal cancer, AIMS Biophysics, 4, (1) pp. 152-177. ISSN 2377-9098 (2017) [Refereed Article]
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Copyright Statement
© 2017 Rajaraman Eri, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0 License (http://creativecommons.org/licenses/by/4.0)
DOI: doi:10.3934/biophy.2017.1.152
Abstract
Inflammatory bowel disease (IBD) is recognized as a leading cause in the development of colorectal cancer (CRC). Inflammatory bowel disease associated colorectal cancer (IBD-CRC) is a growing healthcare burden, causing significant morbidity and mortality world-wide. In the present review, relevant preclinical models of IBD-CRC, a concise overview of potential molecular mechanisms that are involved and responsible for IBD associated colonic tumorigenesis along with the current and the future therapeutic approaches including the role of novel natural and synthetic compounds for the prevention and treatment of IBD-CRC are outlined. This review will benefit various clinicians and translational researchers working in the area of IBD-CRC to have a quick snap-shot of the ongoing trends in IBD-CRC research and discoveries.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Pharmaceutical sciences |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the health sciences |
| UTAS Author: | Shastri, S (Mrs Sonia Shastri) |
| UTAS Author: | Vemuri, R (Mr Ravichandra Vemuri) |
| UTAS Author: | Guven, N (Dr Nuri Guven) |
| UTAS Author: | Shastri, MD (Mr Madhur Shastri) |
| UTAS Author: | Eri, R (Associate Professor Raj Eri) |
| ID Code: | 151485 |
| Year Published: | 2017 |
| Deposited By: | Pharmacy |
| Deposited On: | 2022-07-31 |
| Last Modified: | 2022-09-08 |
| Downloads: | 5 View Download Statistics |
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