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Global emergence and evolutionary dynamics of bluetongue virus
journal contribution
posted on 2023-05-21, 10:04 authored by Alkhamis, MA, Aguilar-Vega, C, Nicholas Fountain-JonesNicholas Fountain-Jones, Lin, K, Perez, AM, Sanchez-Vizcaino, JMBluetongue virus (BTV) epidemics are responsible for worldwide economic losses of up to US$ 3 billion. Understanding the global evolutionary epidemiology of BTV is critical in designing intervention programs. Here we employed phylodynamic models to quantify the evolutionary characteristics, spatiotemporal origins, and multi-host transmission dynamics of BTV across the globe. We inferred that goats are the ancestral hosts for BTV but are less likely to be important for cross-species transmission, sheep and cattle continue to be important for the transmission and maintenance of infection between other species. Our models pointed to China and India, countries with the highest population of goats, as the likely ancestral country for BTV emergence and dispersal worldwide over 1000Â years ago. However, the increased diversification and dispersal of BTV coincided with the initiation of transcontinental livestock trade after the 1850s. Our analysis uncovered important epidemiological aspects of BTV that may guide future molecular surveillance of BTV.
History
Publication title
Scientific ReportsVolume
10Article number
21677Number
21677Pagination
1-12ISSN
2045-2322Department/School
School of Natural SciencesPublisher
Nature Publishing GroupPlace of publication
United KingdomRights statement
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Repository Status
- Open