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Global emergence and evolutionary dynamics of bluetongue virus

Citation

Alkhamis, MA and Aguilar-Vega, C and Fountain-Jones, NM and Lin, K and Perez, AM and Sanchez-Vizcaino, JM, Global emergence and evolutionary dynamics of bluetongue virus, Scientific Reports, 10 Article 21677. ISSN 2045-2322 (2020) [Refereed Article]


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Copyright Statement

© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.1038/s41598-020-78673-9

Abstract

Bluetongue virus (BTV) epidemics are responsible for worldwide economic losses of up to US$ 3 billion. Understanding the global evolutionary epidemiology of BTV is critical in designing intervention programs. Here we employed phylodynamic models to quantify the evolutionary characteristics, spatiotemporal origins, and multi-host transmission dynamics of BTV across the globe. We inferred that goats are the ancestral hosts for BTV but are less likely to be important for cross-species transmission, sheep and cattle continue to be important for the transmission and maintenance of infection between other species. Our models pointed to China and India, countries with the highest population of goats, as the likely ancestral country for BTV emergence and dispersal worldwide over 1000 years ago. However, the increased diversification and dispersal of BTV coincided with the initiation of transcontinental livestock trade after the 1850s. Our analysis uncovered important epidemiological aspects of BTV that may guide future molecular surveillance of BTV.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Virology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Fountain-Jones, NM (Dr Nicholas Fountain-Jones)
ID Code:151433
Year Published:2020
Web of Science® Times Cited:15
Deposited By:Plant Science
Deposited On:2022-07-28
Last Modified:2022-09-01
Downloads:3 View Download Statistics

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