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Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
Citation
Yang, Y and Musco, H and Simpson-Yap, S and Zhu, Z and Wang, Y and Lin, X and Zhang, J and Taylor, B and Gratten, J and Zhou, Y, Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases, Nature Communications, 12 Article 5641. ISSN 2041-1723 (2021) [Refereed Article]
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Copyright Statement
Copyright 2021 the authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1038/s41467-021-25768-0
Abstract
An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and whether consistent genetic relationships exist between MS and the two predominant IBD subtypes, ulcerative colitis (UC) and Crohn’s disease (CD), remains unclear. Here, we use large-scale genome-wide association study summary data to investigate the shared genetic architecture between MS and IBD overall and UC and CD independently. We find a significantly greater genetic correlation between MS and UC than between MS and CD, and identify three SNPs shared between MS and IBD (rs13428812), UC (rs116555563) and CD (rs13428812, rs9977672) in cross-trait meta-analyses. We find suggestive evidence for a causal effect of MS on UC and IBD using Mendelian randomization, but no or weak and inconsistent evidence for a causal effect of IBD or UC on MS. We observe largely consistent patterns of tissue-specific heritability enrichment for MS and IBDs in lung, spleen, whole blood and small intestine, and identify cell-type-specific enrichment for MS and IBDs in CD4+ T cells in lung and CD8+ cytotoxic T cells in lung and spleen. Our study sheds light on the biological basis of comorbidity between MS and IBD.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Medical genetics (excl. cancer genetics) |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the health sciences |
| UTAS Author: | Lin, X (Mr Xin Lin) |
| UTAS Author: | Taylor, B (Professor Bruce Taylor) |
| UTAS Author: | Zhou, Y (Mr Yuan Zhou) |
| ID Code: | 151431 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 13 |
| Deposited By: | Plant Science |
| Deposited On: | 2022-07-28 |
| Last Modified: | 2022-09-09 |
| Downloads: | 3 View Download Statistics |
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