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Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases

Citation

Yang, Y and Musco, H and Simpson-Yap, S and Zhu, Z and Wang, Y and Lin, X and Zhang, J and Taylor, B and Gratten, J and Zhou, Y, Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases, Nature Communications, 12 Article 5641. ISSN 2041-1723 (2021) [Refereed Article]

DOI: doi:10.1038/s41467-021-25768-0

Abstract

An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and whether consistent genetic relationships exist between MS and the two predominant IBD subtypes, ulcerative colitis (UC) and Crohn’s disease (CD), remains unclear. Here, we use large-scale genome-wide association study summary data to investigate the shared genetic architecture between MS and IBD overall and UC and CD independently. We find a significantly greater genetic correlation between MS and UC than between MS and CD, and identify three SNPs shared between MS and IBD (rs13428812), UC (rs116555563) and CD (rs13428812, rs9977672) in cross-trait meta-analyses. We find suggestive evidence for a causal effect of MS on UC and IBD using Mendelian randomization, but no or weak and inconsistent evidence for a causal effect of IBD or UC on MS. We observe largely consistent patterns of tissue-specific heritability enrichment for MS and IBDs in lung, spleen, whole blood and small intestine, and identify cell-type-specific enrichment for MS and IBDs in CD4+ T cells in lung and CD8+ cytotoxic T cells in lung and spleen. Our study sheds light on the biological basis of comorbidity between MS and IBD.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Medical genetics (excl. cancer genetics)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Lin, X (Mr Xin Lin)
UTAS Author:Taylor, B (Professor Bruce Taylor)
UTAS Author:Zhou, Y (Mr Yuan Zhou)
ID Code:151431
Year Published:2021
Web of Science® Times Cited:4
Deposited By:Plant Science
Deposited On:2022-07-28
Last Modified:2022-07-28
Downloads:0

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