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Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening

Citation

Jenkins, MA and Makalic, E and Dowty, JG and Schmidt, DF and Dite, GS and MacInnes, RJ and Ouakrim, DA and Clendenning, M and Flander, LB and Stanesby, OK and Hopper, JL and Win, AK and Buchanan, DD, Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening, Future Oncology, 12, (4) pp. 503-513. ISSN 1479-6694 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Future Medicine Ltd

DOI: doi:10.2217/fon.15.303

Abstract

Aim: To determine whether single nucleotide polymorphisms (SNPs) can be used to identify people who should be screened for colorectal cancer.

Methods: We simulated one million people with and without colorectal cancer based on published SNP allele frequencies and strengths of colorectal cancer association. We estimated 5-year risks of colorectal cancer by number of risk alleles.

Results: We identified 45 SNPs with an average 1.14-fold increase colorectal cancer risk per allele (range: 1.05-1.53). The colorectal cancer risk for people in the highest quintile of risk alleles was 1.81-times that for the average person.

Conclusion: We have quantified the extent to which known susceptibility SNPs can stratify the population into clinically useful colorectal cancer risk categories.

Item Details

Item Type:Refereed Article
Keywords:cancer screening, colorectal cancer, single nucleotide polymorphisms, risk prediction
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Stanesby, OK (Mr Oliver Stanesby)
ID Code:151419
Year Published:2016
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-07-28
Last Modified:2022-09-08
Downloads:0

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