Jenkins, MA and Makalic, E and Dowty, JG and Schmidt, DF and Dite, GS and MacInnes, RJ and Ouakrim, DA and Clendenning, M and Flander, LB and Stanesby, OK and Hopper, JL and Win, AK and Buchanan, DD, Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening, Future Oncology, 12, (4) pp. 503-513. ISSN 1479-6694 (2016) [Refereed Article]
Copyright 2016 Future Medicine Ltd
Aim: To determine whether single nucleotide polymorphisms (SNPs) can be used to identify people who should be screened for colorectal cancer.
Methods: We simulated one million people with and without colorectal cancer based on published SNP allele frequencies and strengths of colorectal cancer association. We estimated 5-year risks of colorectal cancer by number of risk alleles.
Results: We identified 45 SNPs with an average 1.14-fold increase colorectal cancer risk per allele (range: 1.05-1.53). The colorectal cancer risk for people in the highest quintile of risk alleles was 1.81-times that for the average person.
Conclusion: We have quantified the extent to which known susceptibility SNPs can stratify the population into clinically useful colorectal cancer risk categories.
|Item Type:||Refereed Article|
|Keywords:||cancer screening, colorectal cancer, single nucleotide polymorphisms, risk prediction|
|Research Division:||Health Sciences|
|Research Field:||Epidemiology not elsewhere classified|
|Objective Group:||Clinical health|
|Objective Field:||Prevention of human diseases and conditions|
|UTAS Author:||Stanesby, OK (Mr Oliver Stanesby)|
|Web of Science® Times Cited:||28|
|Deposited By:||Menzies Institute for Medical Research|
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