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Missing data in palliative care research: estimands and estimators

Citation

Roydhouse, JP and Floden, L and Braat, S and Grobler, A and Kochovska, S and Currow, DC and Bell, ML, Missing data in palliative care research: estimands and estimators, BMJ Supportive & Palliative Care ISSN 2045-435X (2022) [Refereed Article]


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DOI: doi:10.1136/bmjspcare-2022-003553

Abstract

There are several methodological challenges when conducting randomised controlled trials in palliative care. These include worsening function and high mortality, leading to treatment discontinuation, some of which will be unrelated to the intervention being evaluated.

Recently, a new framework for handling postrandomisation events, such as attrition, has been released. This framework aims to align trial objectives, design, conduct and analysis by clarifying what and how to estimate treatment effects in the presence of data affected by postrandomisation events.

The purpose of this paper is to introduce palliative care researchers to this framework and how it can guide trial design, and efficacy and safety analysis in a palliative care context where individual withdrawal from the trial is common.

In this paper, we describe the estimand framework and the background for it. We also consider postrandomisation events that are frequently encountered in palliative care trials and how these might affect objectives of interest. We then construct efficacy and safety estimands for a trial in palliative care. Better trial design and alignment of objectives with analysis can improve our understanding of what treatments do and do not work in palliative care.

Item Details

Item Type:Refereed Article
Keywords:estimators, estimands, palliative care
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Palliative care
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health outcomes
UTAS Author:Roydhouse, JP (Dr Jessica Roydhouse)
ID Code:151282
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-07-26
Last Modified:2022-07-26
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