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Malate Circulation: Linking Chloroplast Metabolism to Mitochondrial ROS


Zhao, Y and Yu, H and Zhou, JM and Smith, SM and Li, J, Malate Circulation: Linking Chloroplast Metabolism to Mitochondrial ROS, Trends in Plant Science, 25, (5) pp. 446-454. ISSN 1878-4372 (2020) [Refereed Article]

DOI: doi:10.1016/j.tplants.2020.01.010


In photosynthetic cells, chloroplasts and mitochondria are the sites of the core redox reactions underpinning energy metabolism. Such reactions generate reactive oxygen species (ROS) when oxygen is partially reduced. ROS signaling leads to responses by cells which enable them to adjust to changes in redox status. Recent studies in Arabidopsis thaliana reveal that chloroplast NADH can be used to generate malate which is exported to the mitochondrion where its oxidation regenerates NADH. Oxidation of this NADH produces mitochondrial ROS (mROS) which can activate signaling systems to modulate energy metabolism, and in certain cases can lead to programmed cell death (PCD). We propose the term ‘malate circulation’ to describe such redistribution of reducing equivalents to mediate energy homeostasis in the cell.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Plant biology
Research Field:Plant physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Smith, SM (Professor Steven Smith)
ID Code:151169
Year Published:2020
Web of Science® Times Cited:50
Deposited By:Plant Science
Deposited On:2022-07-23
Last Modified:2022-07-23

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