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Malate Circulation: Linking Chloroplast Metabolism to Mitochondrial ROS
journal contribution
posted on 2023-05-21, 09:41 authored by Zhao, Y, Yu, H, Zhou, JM, Steven SmithSteven Smith, Li, JIn photosynthetic cells, chloroplasts and mitochondria are the sites of the core redox reactions underpinning energy metabolism. Such reactions generate reactive oxygen species (ROS) when oxygen is partially reduced. ROS signaling leads to responses by cells which enable them to adjust to changes in redox status. Recent studies in Arabidopsis thaliana reveal that chloroplast NADH can be used to generate malate which is exported to the mitochondrion where its oxidation regenerates NADH. Oxidation of this NADH produces mitochondrial ROS (mROS) which can activate signaling systems to modulate energy metabolism, and in certain cases can lead to programmed cell death (PCD). We propose the term ‘malate circulation’ to describe such redistribution of reducing equivalents to mediate energy homeostasis in the cell.
History
Publication title
Trends in Plant ScienceVolume
25Issue
5Pagination
446-454ISSN
1878-4372Department/School
School of Natural SciencesPublisher
Elsevier Ltd. * Trends JournalsPlace of publication
United KingdomRepository Status
- Restricted