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Prophylactic cefazolin dosing in obesity - a systematic review


Coates, M and Shield, A and Peterson, GM and Hussain, Z, Prophylactic cefazolin dosing in obesity - a systematic review, Obesity Surgery, 32, (9) pp. 3138-3149. ISSN 0960-8923 (2022) [Refereed Article]

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DOI: doi:10.1007/s11695-022-06196-5


Currently, there is no consensus on whether a standard 2-g prophylactic cefazolin dose provides sufficient antimicrobial coverage in obese surgical patients. This systematic review analysed both outcome and pharmacokinetic studies, aiming to determine the appropriate cefazolin dose. A systematic search was conducted using 4 databases. In total, 3 outcome and 15 pharmacokinetic studies met the inclusion criteria. All 3 outcome studies concluded that there is no need for increased dose. Also, 9 pharmacokinetic studies reached this conclusion; however, 6 pharmacokinetic studies recommended that 2-g dose is insufficient to achieve adequate plasma or tissue concentrations. The stronger body of evidence supports that 2-g dose of cefazolin is sufficient for surgery lasting up to 4 h; however, large-scale outcome studies are needed to confirm this evidence.

Item Details

Item Type:Refereed Article
Keywords:obesity, cefazolin, dosing, surgical site infection, prophylaxis
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Efficacy of medications
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:150996
Year Published:2022
Deposited By:Pharmacy
Deposited On:2022-07-10
Last Modified:2022-09-20

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