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Prophylactic cefazolin dosing in obesity - a systematic review
Citation
Coates, M and Shield, A and Peterson, GM and Hussain, Z, Prophylactic cefazolin dosing in obesity - a systematic review, Obesity Surgery, 32, (9) pp. 3138-3149. ISSN 0960-8923 (2022) [Refereed Article]
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DOI: doi:10.1007/s11695-022-06196-5
Abstract
Currently, there is no consensus on whether a standard 2-g prophylactic cefazolin dose provides sufficient antimicrobial coverage in obese surgical patients. This systematic review analysed both outcome and pharmacokinetic studies, aiming to determine the appropriate cefazolin dose. A systematic search was conducted using 4 databases. In total, 3 outcome and 15 pharmacokinetic studies met the inclusion criteria. All 3 outcome studies concluded that there is no need for increased dose. Also, 9 pharmacokinetic studies reached this conclusion; however, 6 pharmacokinetic studies recommended that 2-g dose is insufficient to achieve adequate plasma or tissue concentrations. The stronger body of evidence supports that 2-g dose of cefazolin is sufficient for surgery lasting up to 4 h; however, large-scale outcome studies are needed to confirm this evidence.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | obesity, cefazolin, dosing, surgical site infection, prophylaxis |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Clinical pharmacology and therapeutics |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Efficacy of medications |
| UTAS Author: | Peterson, GM (Professor Gregory Peterson) |
| ID Code: | 150996 |
| Year Published: | 2022 |
| Deposited By: | Pharmacy |
| Deposited On: | 2022-07-10 |
| Last Modified: | 2022-09-20 |
| Downloads: | 0 |
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