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Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Citation

Nuotio, J and Laitinen, TT and Sinaiko, AR and Woo, JG and Urbina, EM and Jacobs, DR and Steinberger, J and Prineas, RJ and Sabin, MA and Burgner, DP and Minn, H and Burns, TL and Bazzano, LA and Venn, A and Viikari, JSA and Hutri-Kahonen, N and Daniels, SR and Raitakari, OT and Magnussen, CG and Juonala, M and Dwyer, T, Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium, International Journal of Obesity, 46 pp. 393-399. ISSN 0307-0565 (2022) [Refereed Article]


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DOI: doi:10.1038/s41366-021-01000-3

Abstract

Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce.

Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3-19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries.

Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03-1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01-1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03-1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12-1.63).

Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.

Item Details

Item Type:Refereed Article
Keywords:obesity, childhood, cancer, mortality, BMI, blood pressure, glucose, lipid
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Oncology and carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Overweight and obesity
UTAS Author:Venn, A (Professor Alison Venn)
ID Code:150902
Year Published:2022
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-07-04
Last Modified:2022-07-18
Downloads:0

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