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Associations of a healthy lifestyle score from childhood to adulthood with subclinical kidney damage in midlife: a population-based cohort study


Liu, C and Tian, J and Jose, MD and He, Y and Dwyer, T and Venn, AJ, Associations of a healthy lifestyle score from childhood to adulthood with subclinical kidney damage in midlife: a population-based cohort study, BMC Nephrology, 23 Article 2. ISSN 1471-2369 (2022) [Refereed Article]

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2021. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.1186/s12882-021-02627-0


Background: The relationships of healthy lifestyle scores (HLS) of various kinds in adulthood with the risk of chronic kidney disease (CKD) have been reported, but little is known about the association of childhood lifestyle with later life CKD. This study examined the relationship of HLS from childhood to adulthood with subclinical kidney damage (SKD) in midlife, a surrogate measure for CKD.

Methods: Data were collected in an Australian population-based cohort study with 33 years follow-up. 750 participants with lifestyle information collected in childhood (ages 10-15 years) and midlife (ages 40-50 years), and measures of kidney function in midlife were included. The HLS was generated from the sum scores of five lifestyle factors (body mass index, smoking, alcohol consumption, physical activity, and diet). Each factor was scored as poor (0 point), intermediate (1 point), or ideal (2 points). Log-binomial regression was used to investigate the relationship of HLS in childhood and from childhood to adulthood with SKD defined as either 1) estimated glomerular filtration rate (eGFR) 30-60 mL/min/1.73m2 or 2) eGFR> 60 mL/min/1.73m2 with urine albumin-creatinine ratio ≥ 2.5 mg/mmol (males) or 3.5 mg/mmol (females), adjusting for socio-demographic factors and the duration of follow-up.

Results: The average HLS was 6.6 in childhood and 6.5 in midlife, and the prevalence of SKD was 4.9% (n = 36). Neither HLS in childhood nor HLS from childhood to adulthood were significantly associated with the risk of SKD in midlife.

Conclusions: A HLS from childhood to adulthood did not predict SKD in this middle-aged, population-based Australian cohort.

Item Details

Item Type:Refereed Article
Keywords:healthy lifestyle, longitudinal studies, chronic kidney disease, child, adult
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Specific population health (excl. Indigenous health) not elsewhere classified
UTAS Author:Liu, C (Miss Conghui Liu)
UTAS Author:Tian, J (Dr Jing Tian)
UTAS Author:Jose, MD (Professor Matthew Jose)
UTAS Author:He, Y (Ms Ye He)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Venn, AJ (Professor Alison Venn)
ID Code:150900
Year Published:2022
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-07-04
Last Modified:2022-08-11

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