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Muscular strength measured across the life-course and the metabolic syndrome


Fraser, BJ and Blizzard, L and Buscot, M-J and Schmidt, MD and Dwyer, T and Venn, AJ and Magnussen, CG, Muscular strength measured across the life-course and the metabolic syndrome, Nutrition, Metabolism and Cardiovascular Diseases, 32, (5) pp. 1131-1137. ISSN 0939-4753 (2022) [Refereed Article]

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DOI: doi:10.1016/j.numecd.2022.01.018


Background and aims: Low muscular strength associates with the metabolic syndrome (MetS). However, how muscular strength measured at different life stages contribute to the development of MetS is unknown. This study compared the contribution of muscular strength measured in youth, young- and mid-adulthood with MetS in midlife.

Methods and results: Prospective longitudinal study of 267 Childhood Determinants of Adult Health Study participants who between 1985 and 2019 had measures of muscular strength (dominant grip strength) at three life stages (youth = 9-15 years, young adulthood = 26-36 years, mid-adulthood = 36-49 years) and had their MetS status assessed in mid-adulthood. Bayesian relevant life-course exposure models quantified associations between muscular strength at each life stage with MetS and estimated the maximum accumulated effect of lifelong muscular strength. The contribution of muscular strength at each life stage with MetS was equal (youth = 38%, young adulthood = 28%, mid-adulthood = 34%). A one standard deviation increase in cumulative muscular strength was associated with 46% reduced odds of MetS. Of all MetS components, muscular strength was most strongly negatively associated with high waist circumference.

Conclusion: A life-course approach demonstrated reduced odds of MetS in midlife was associated with cumulatively high muscular strength since youth. This supports efforts to promote physical fitness throughout life.

Item Details

Item Type:Refereed Article
Keywords:Bayesian analysis, muscle strength, muscular strength, epidemiology, cohort studies, metabolic syndrome
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Sports medicine
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Fraser, BJ (Dr Brooklyn Fraser)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Buscot, M-J (Dr Marie-Jeanne Buscot)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Venn, AJ (Professor Alison Venn)
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
ID Code:150897
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-07-04
Last Modified:2022-07-15

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