Singh, A and Venn, A and Blizzard, L and Jones, G and Burgess, J and Parameswaran, V and Cicuttini, F and March, L and Eckstein, F and Wirth, W and Ding, C and Antony, B, Association between osteoarthritis-related serum biochemical markers over 11 years and knee MRI-based imaging biomarkers in middle-aged adults, Osteoarthritis and Cartilage, 30, (5) pp. 756-764. ISSN 1063-4584 (2022) [Refereed Article]
Objective: To describe the associations between osteoarthritis (OA)-related biochemical markers (COMP, MMP-3, HA) and MRI-based imaging biomarkers in middle-aged adults over 10-13 years.
Methods: Blood serum samples collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year:2004-06; n = 156) and 10-13 year follow-up at CDAH-3 (n = 167) were analysed for COMP, MMP-3, and HA using non-isotopic ELISA. Knee MRI scans obtained during the CDAH-knee study (year:2008-10; n = 313) were assessed for cartilage volume and thickness, subchondral bone area, cartilage defects, and BML.
Results: In a multivariable linear regression model describing the association of baseline biochemical markers with MRI-markers (assessed after 4-years), we found a significant negative association of standardised COMP with medial femorotibial compartment cartilage thickness (β:-0.070; 95%CI:-0.138,-0.001), and standardised MMP-3 with patellar cartilage volume (β:-141.548; 95%CI:-254.917,-28.179) and total bone area (β:-0.729; 95%CI:-1.340,-0.118). In multivariable Tobit regression model, there was a significant association of MRI-markers with biochemical markers (assessed after 6-9 years); a significant negative association of patellar cartilage volume (β:-0.001; 95%CI:-0.002,-0.00004), and total bone area (β:-0.158; 95%CI-0.307,-0.010) with MMP-3, and total cartilage volume (β:-0.001; 95%CI:-0.001,-0.0001) and total bone area (β:-0.373; 95%CI:-0.636,-0.111) with COMP. No significant associations were observed between MRI-based imaging biomarkers and HA.
Conclusion: COMP and MMP-3 levels were negatively associated with knee cartilage thickness and volume assessed 4-years later, respectively. Knee cartilage volume and bone area were negatively associated with COMP and MMP-3 levels assessed 6-9 years later. These results suggest that OA-related biochemical markers and MRI-markers are interrelated in early OA.
|Item Type:||Refereed Article|
|Keywords:||osteoarthritis, biomarkers, magnetic resonance imaging, MRI, cartilage degradation, metalloproteinase, serum biochemical markers|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Public health (excl. specific population health) not elsewhere classified|
|UTAS Author:||Singh, A (Mr Ambrish Singh)|
|UTAS Author:||Venn, A (Professor Alison Venn)|
|UTAS Author:||Blizzard, L (Professor Leigh Blizzard)|
|UTAS Author:||Jones, G (Mr Gareth Jones)|
|UTAS Author:||Burgess, J (Mr James Burgess)|
|UTAS Author:||Parameswaran, V (Associate Professor Venkat Parameswaran)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|Deposited By:||Menzies Institute for Medical Research|
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