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Association between osteoarthritis-related serum biochemical markers over 11 years and knee MRI-based imaging biomarkers in middle-aged adults


Singh, A and Venn, A and Blizzard, L and Jones, G and Burgess, J and Parameswaran, V and Cicuttini, F and March, L and Eckstein, F and Wirth, W and Ding, C and Antony, B, Association between osteoarthritis-related serum biochemical markers over 11 years and knee MRI-based imaging biomarkers in middle-aged adults, Osteoarthritis and Cartilage, 30, (5) pp. 756-764. ISSN 1063-4584 (2022) [Refereed Article]

Copyright Statement

2022 Osteoarthritis Research Society International. Published by Elsevier Ltd.

DOI: doi:10.1016/j.joca.2022.02.616


Objective: To describe the associations between osteoarthritis (OA)-related biochemical markers (COMP, MMP-3, HA) and MRI-based imaging biomarkers in middle-aged adults over 10-13 years.

Methods: Blood serum samples collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year:2004-06; n= 156) and 10-13 year follow-up at CDAH-3 (n= 167) were analysed for COMP, MMP-3, and HA using non-isotopic ELISA. Knee MRI scans obtained during the CDAH-knee study (year:2008-10; n= 313) were assessed for cartilage volume and thickness, subchondral bone area, cartilage defects, and BML.

Results: In a multivariable linear regression model describing the association of baseline biochemical markers with MRI-markers (assessed after 4-years), we found a significant negative association of standardised COMP with medial femorotibial compartment cartilage thickness (β:-0.070; 95%CI:-0.138,-0.001), and standardised MMP-3 with patellar cartilage volume (β:-141.548; 95%CI:-254.917,-28.179) and total bone area (β:-0.729; 95%CI:-1.340,-0.118). In multivariable Tobit regression model, there was a significant association of MRI-markers with biochemical markers (assessed after 6-9 years); a significant negative association of patellar cartilage volume (β:-0.001; 95%CI:-0.002,-0.00004), and total bone area (β:-0.158; 95%CI-0.307,-0.010) with MMP-3, and total cartilage volume (β:-0.001; 95%CI:-0.001,-0.0001) and total bone area (β:-0.373; 95%CI:-0.636,-0.111) with COMP. No significant associations were observed between MRI-based imaging biomarkers and HA.

Conclusion: COMP and MMP-3 levels were negatively associated with knee cartilage thickness and volume assessed 4-years later, respectively. Knee cartilage volume and bone area were negatively associated with COMP and MMP-3 levels assessed 6-9 years later. These results suggest that OA-related biochemical markers and MRI-markers are interrelated in early OA.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, biomarkers, magnetic resonance imaging, MRI, cartilage degradation, metalloproteinase, serum biochemical markers
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Singh, A (Mr Ambrish Singh)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Jones, G (Mr Gareth Jones)
UTAS Author:Burgess, J (Mr James Burgess)
UTAS Author:Parameswaran, V (Associate Professor Venkat Parameswaran)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
ID Code:150895
Year Published:2022
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-07-04
Last Modified:2022-11-10

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