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Childhood cardiorespiratory fitness and the early markers of kidney disease in middle age: A population-based cohort study

Citation

Liu, C and Fraser, BJ and He, Y and Jose, MD and Magnussen, CG and Tian, J and Dwyer, T and Venn, AJ, Childhood cardiorespiratory fitness and the early markers of kidney disease in middle age: A population-based cohort study, Journal of Science and Medicine in Sport, 25, (6) pp. 499-504. ISSN 1440-2440 (2022) [Refereed Article]

Copyright Statement

Copyright 2022 Sports Medicine Australia

DOI: doi:10.1016/j.jsams.2022.03.005

Abstract

Objectives: To investigate the relationship of childhood cardiorespiratory fitness with early markers of chronic kidney disease, glomerular hyperfiltration and albuminuria, in midlife.

Design: Prospective cohort study.

Methods: This study included 1371 participants aged 36-49 years who participated in the 1985 Australian Schools Health and Fitness Survey when they were 7-15 years of age. Childhood cardiorespiratory fitness was estimated by the time taken to complete a 1.6- km run. Blood and urine samples were collected at follow-up. Log-binomial regression was used to determine the associations of childhood cardiorespiratory fitness with glomerular hyperfiltration [estimated glomerular filtration rate (mL/min/1.73 m2) > 95th percentile standardized for age and sex] and albuminuria (urine albumin-to-creatinine ratio ≥ 2.5 mg/mmol in males or ≥3.5 mg/mmol in females) in midlife.

Results: Compared with women with high childhood cardiorespiratory fitness, those with lower childhood cardiorespiratory fitness had a higher risk of glomerular hyperfiltration in midlife after adjusting for childhood age, the duration of follow-up, and midlife smoking status [adjusted relative risk = 2.86, 95% confidence interval, 1.04-7.86 for individuals with moderate childhood cardiorespiratory fitness (P = 0.04), and adjusted relative risk = 3.38, 95% confidence interval, 1.13-10.14 for individuals with low childhood cardiorespiratory fitness (P = 0.03)]. Further adjustment for childhood and midlife body mass index resulted in a slightly attenuated and statistically non-significant association. No significant associations were found with glomerular hyperfiltration in males or albuminuria in either males or females.

Conclusions: Low cardiorespiratory fitness in childhood may increase the risk of glomerular hyperfiltration in midlife in females, possibly via a path through adult cardiorespiratory fitness.

Item Details

Item Type:Refereed Article
Keywords:cardiorespiratory fitness, glomerular hyperfiltration, albuminuria, kidney disease, child, adult
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiovascular medicine and haematology not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Liu, C (Miss Conghui Liu)
UTAS Author:Fraser, BJ (Dr Brooklyn Fraser)
UTAS Author:He, Y (Ms Ye He)
UTAS Author:Jose, MD (Professor Matthew Jose)
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
UTAS Author:Tian, J (Dr Jing Tian)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Venn, AJ (Professor Alison Venn)
ID Code:150885
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-07-04
Last Modified:2022-09-30
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