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Calcium signalling in medulloblastoma: an in silico analysis of the expression of calcium regulating genes in patient samples

Citation

Maklad, A and Sedeeq, M and Milevskiy, MJG and Azimi, I, Calcium signalling in medulloblastoma: an in silico analysis of the expression of calcium regulating genes in patient samples, Genes, 12, (9) Article 1329. ISSN 2073-4425 (2021) [Refereed Article]


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Copyright Statement

Copyright: 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).

DOI: doi:10.3390/genes12091329

Abstract

Dysregulation in calcium signalling is implicated in several cancer-associated processes, including cell proliferation, migration, invasion and therapy resistance. Modulators of specific calcium-regulating proteins have been proposed as promising future therapeutic agents for some cancers. Alterations in calcium signalling have been extensively studied in some cancers; however, this area of research is highly underexplored in medulloblastoma (MB), the most common paediatric malignant brain tumour. Current MB treatment modalities are not completely effective and can result in several long-lasting mental complications. Hence, new treatment strategies are needed. In this study, we sought to probe the landscape of calcium signalling regulators to uncover those most likely to be involved in MB tumours. We investigated the expression of calcium signalling regulator genes in MB patients using publicly available datasets. We stratified the expression level of these genes with MB molecular subgroups, tumour metastasis and patient survival to uncover correlations with clinical features. Of particular interest was CACNA1 genes, in which we were able to show a developmentally-driven change in expression within the cerebellum, MB's tissue of origin, highlighting a potential influence on tumour incidence. This study lays a platform for future investigations into molecular regulators of calcium signalling in MB formation and progression.

Item Details

Item Type:Refereed Article
Keywords:calcium signalling, medulloblastoma, gene expression, in silico analysis
Research Division:Biological Sciences
Research Group:Bioinformatics and computational biology
Research Field:Genomics and transcriptomics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Maklad, A (Mr Ahmed Maklad)
UTAS Author:Sedeeq, M (Mr Mohammed Sedeeq)
UTAS Author:Azimi, I (Dr Iman Azimi)
ID Code:150811
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Pharmacy
Deposited On:2022-07-01
Last Modified:2022-08-04
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