Campbell, JA and Ahmad, H and Chen, G and van der Mei, I and Taylor, B and Claflin, S and Henson, GJ and Simpson-Yap, S and Laslett, L and Hawkes, K and Hust, C and Waugh, H and Palmer, AJ, Validation of the EQ-5D-5L and psychosocial bolt-ons in a large cohort of people living with multiple sclerosis in Australia, Quality of Life Research ISSN 0962-9343 (In Press) [Refereed Article]
Background: Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the central nervous system which results in disability over time and reduced quality-of-life. To increase the sensitivity of the EQ-5D-5L for psychosocial health, four bolt-on items from the AQoL-8D were used to create the 9-item EQ-5D-5L-Psychosocial. We aimed to externally validate the EQ-5D-5L-Psychosocial in a large cohort of people with MS (PwMS) and explore the discriminatory power of the new instrument with EQ-5D-5L/AQoL-8D.
Methods: A large representative sample from the Australian MS Longitudinal Study completed the AQoL-8D and EQ-5D-5L (including EQ VAS) and both instruments health state utilities (HSUs) were scored using Australian tariffs. Sociodemographic/clinical data were also collected. External validity of EQ-5D-5L-Psychosocial scoring algorithm was assessed with mean absolute errors (MAE) and Spearman’s correlation coefficient. Discriminatory sensitivity was assessed with an examination of ceiling/floor effects, and disability severity classifications.
Results: Among 1,683 participants (mean age: 58.6 years; 80% female), over half (55%) had moderate or severe disability. MAE (0.063) and the distribution of the prediction error were similar to the original development study. Mean(±standard deviation) HSUs were EQ-5D-5L: 0.58±0.32, EQ-5D-5L-Psychosocial 0.62±0.29, and AQoL-8D: 0.63±0.20. N=157 (10%) scored perfect health (i.e., HSU=1.0) on the EQ-5D-5L, but reported a mean HSU of 0.90 on the alternative instruments. The Sleep bolt-on dimension was particularly important for PwMS.
Conclusions: The EQ-5D-5L-Psychosocial is more sensitive than the EQ-5D-5L in pwMS whose HSUs approach those reflecting full health. When respondent burden is taken into account, the EQ-5D-5L-Psychosocial is preferential to the AQoL-8D. We suggest a larger confirmatory study comparing all prevalent multi-attribute utility instruments for PwMS.
|Item Type:||Refereed Article|
|Keywords:||Multiple sclerosis, Australian MS Longitudinal Study, multi-attribute utility instrument, EQ-5D-5L, AQoL-8D, EQ-5D-5L-Psychosocial, cost-utility analysis, sleep, AQoL-8D, economic evaluation, health state utilities, quality of life|
|Research Group:||Applied economics|
|Research Field:||Health economics|
|Objective Group:||Evaluation of health and support services|
|Objective Field:||Evaluation of health outcomes|
|UTAS Author:||Campbell, JA (Dr Julie Campbell)|
|UTAS Author:||Ahmad, H (Dr Hasnat Ahmad)|
|UTAS Author:||van der Mei, I (Professor Ingrid van der Mei)|
|UTAS Author:||Taylor, B (Professor Bruce Taylor)|
|UTAS Author:||Claflin, S (Dr Suzi Claflin)|
|UTAS Author:||Henson, GJ (Mr Glen Henson)|
|UTAS Author:||Laslett, L (Dr Laura Laslett)|
|UTAS Author:||Hawkes, K (Dr Kirsty Hawkes)|
|UTAS Author:||Waugh, H (Ms Hilary Waugh)|
|UTAS Author:||Palmer, AJ (Professor Andrew Palmer)|
|Year Published:||In Press|
|Deposited By:||Menzies Institute for Medical Research|
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