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Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis


Ma, S and Su, W and Sun, C and Lowe, S and Zhou, Z and Liu, X and Qu, G and Xia, W and Xie, P and Wu, B and Gao, J and Feng, L and Sun, Y, Does aspirin have an effect on risk of death in patients with COVID-19? A meta-analysis, European Journal of Clinical Pharmacology pp. 1-18. ISSN 0031-6970 (2022) [Refereed Article]

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DOI: doi:10.1007/s00228-022-03356-5



The coronavirus disease 2019 (COVID-19) pandemic has shown unprecedented impact world-wide since the eruption in late 2019. Importantly, emerging reports suggest an increased risk of thromboembolism development in patients with COVID-19. Meanwhile, it is found that aspirin reduced mortality in critically ill patients with non-COVID-19 acute respiratory distress syndrome. Therefore, a meta-analysis was performed to investigate the effects of aspirin on COVID-19 mortality.


A systematic literature search was conducted in 10 electronic databases and 4 registries. Random effects models were used to calculate pooled relative risks (RRs) with 95% confidence intervals (Cis) to estimate the effect of aspirin on COVID-19 mortality. Relevant subgroup analyses and sensitivity analyses were also performed.


The results showed that aspirin use was associated with a reduction in COVID-19 mortality (adjusted RR 0.69; 95% CI 0.500.95; P < 0.001). Subgroup analysis found that the low-dose group was associated with a reduced COVID-19 mortality (adjusted RR 0.64; 95% CI 0.480.85; P < 0.01). Aspirin use was associated with reduced COVID-19 mortality in Europe and America (crude RR 0.71; 95% CI 0.520.98; P = 0.04), and results from cohort studies suggested that aspirin use was a protective factor for COVID-19 mortality (adjusted RR 0.73; 95% CI 0.520.99; P = 0.04). Meanwhile, aspirin use was not associated with bleeding risk (crude RR 1.22; 95% CI 0.801.87; P = 0.96).


This meta-analysis found that aspirin use was associated with a reduction in mortality in patients with COVID-19 and not with an increased risk of bleeding.

Item Details

Item Type:Refereed Article
Keywords:aspirin, COVID-19, mortality, meta-analysis
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Efficacy of medications
UTAS Author:Zhou, Z (Dr Zhen Zhou)
ID Code:150656
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-06-23
Last Modified:2022-06-26

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