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Laxative use amongst Tasmanian aged care residents receiving controlled released (CR) oxycodone products and other opioids

Citation

Thompson, A and Ooi, CJ and Veal, F and Curtain, C and Williams, M, Laxative use amongst Tasmanian aged care residents receiving controlled released (CR) oxycodone products and other opioids, National Medicines Symposium, 7 December, Online Web Conference (2020) [Conference Extract]


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Abstract

Background
Opioid induced constipation (OIC) is a common and often persistent problem
Management of OIC has traditionally relied on the use of laxatives
However recent years have seen peripheral opioid receptor antagonists (PORAs) emerge as another option
The most widely used PORA is naloxone, given as oxycodone/naloxone CR
Oxycodone/naloxone CR is the most prescribed long-acting opioid in Australia:
- 1.74 million prescriptions in the year to June 30th 2019
- Associated cost to government was $79.8million
Oxycodone/naloxone CR is reported to be associated with less OIC than standard oxycodone CR, which is now available generically
However little is known about the prevalence of laxative use in those who take oxycodone/naloxone CR and how this compares with other opioids

Method
Retrospective review of data collected during medication reviews for Tasmanian aged care facility (ACF) residents
Comparison of laxative use amongst Tasmanian ACF residents prescribed oxycodone/naloxone CR or other opioids

Findings
278 (31.7%) of 878 residents in 15 ACFs were using regular opioids
Prevalence of regular laxative use:
- 51.4% in those taking oxycodone/naloxone CR
- 53% in those taking other opioids
- 56.6% in those taking other strong opioids

Conclusion
Over half of ACF residents taking regular oxycodone/naloxone CR are taking regular laxatives
Laxative use may be slightly less prevalent in those taking oxycodone/naloxone CR than other strong opioids
However, is this sufficient to justify the price premium that the PBS pays for oxycodone/naloxone CR?

Item Details

Item Type:Conference Extract
Keywords:oxycodone, laxative use, aged care residents
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Clinical health
Objective Field:Human pain management
UTAS Author:Thompson, A (Mr Angus Thompson)
UTAS Author:Ooi, CJ (Miss OOi)
UTAS Author:Veal, F (Dr Felicity Veal)
UTAS Author:Curtain, C (Mr Colin Curtain)
UTAS Author:Williams, M (Dr Mackenzie Williams)
ID Code:150581
Year Published:2020
Deposited By:Pharmacy
Deposited On:2022-06-21
Last Modified:2022-07-05
Downloads:0

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