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Poor sleep and multiple sclerosis: associations with symptoms of multiple sclerosis and quality of life

Citation

Laslett, LL and Honan, C and Turner, JA and Dagnew-Mekonnon, B and Campbell, JA and Gill, TK and Appleton, S and Blizzard, L and Taylor, BV and van der Mei, I, Poor sleep and multiple sclerosis: associations with symptoms of multiple sclerosis and quality of life, Journal of Neurology Neurosurgery and Psychiatry ISSN 0022-3050 (In Press) [Refereed Article]


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Abstract

Background: Sleep difficulties are common in people with MS, but whether associations between poor sleep quality and quality of life are independent of MS symptoms, obesity, and other MS-related factors remains unclear.

Methods: Cross-sectional analyses of data from the Australian MS Longitudinal Study (n=1,717). Sleep was assessed using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and International Restless Legs Syndrome Study Group Rating Scale; health-related quality of life using the Assessment of Quality-of-Life 8-D.

Results: Poor sleep quality was common (67%), and more common than in community samples. Sleep measures clustered independently within MS symptoms. The clusters ‘fatigue and cognitive’, ‘feelings of anxiety and depression’, ‘pain and sensory’, were independently associated with poor sleep quality. Quality-of-Life utility scores were a clinically meaningful 0.19 units lower in those with poor sleep. Sleep quality, daytime sleepiness, and restless leg syndrome were associated with reduced quality of life, independent of MS-related symptoms and body mass index.

Conclusion: Poor sleep quality is common in MS and was strongly associated with worse health-related quality of life, independent of other MS symptoms and did not cluster with other common MS symptoms. Improving sleep quality may substantially improve quality of life in people with MS.

Item Details

Item Type:Refereed Article
Keywords:Multiple sclerosis, symptoms, sleep, sleep quality, quality of life
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health outcomes
UTAS Author:Laslett, LL (Dr Laura Laslett)
UTAS Author:Honan, C (Dr Cynthia Honan)
UTAS Author:Turner, JA (Mr Jason Turner)
UTAS Author:Dagnew-Mekonnon, B (Mr Baye Dagnew-Mekonnon)
UTAS Author:Campbell, JA (Dr Julie Campbell)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
ID Code:150321
Year Published:In Press
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-06-08
Last Modified:2022-06-08
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