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Generation and characterisation of four multiple sclerosis iPSC lines from a single family


Fortune, AJ and Taylor, BV and Charlesworth, JC and Burdon, KP and Blackburn, NB and Fletcher, JL and Mehta, A and Young, KM, Generation and characterisation of four multiple sclerosis iPSC lines from a single family, Stem Cell Research, 62 Article 102828. ISSN 1873-5061 (2022) [Refereed Article]

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Copyright Statement

2022 The Authors. Published by Elsevier B.V. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license,

DOI: doi:10.1016/j.scr.2022.102828


Multiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account for ∼48% of MS risk (International Multiple Sclerosis Genetics Consortium, 2019). Despite this, families with a high incidence of MS are rare. We have generated four induced pluripotent stem cell (iPSC) lines from individuals with relapsing-remitting and secondary progressive MS within a single family. The generation of disease-specific iPSC lines from multiple members of a single family will facilitate MS genetic and functional studies.

Item Details

Item Type:Refereed Article
Keywords:Induced pluripotent stem cells, multiple sclerosis, neurodegenerative disease, reprogramming, iPSC, genetics
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Medical genetics (excl. cancer genetics)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Fortune, AJ (Mr Alastair Fortune)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
UTAS Author:Charlesworth, JC (Dr Jac Charlesworth)
UTAS Author:Burdon, KP (Professor Kathryn Burdon)
UTAS Author:Blackburn, NB (Dr Nicholas Blackburn)
UTAS Author:Fletcher, JL (Dr Jessica Fletcher)
UTAS Author:Mehta, A (Dr Ashish Mehta)
UTAS Author:Young, KM (Professor Kaylene Young)
ID Code:150294
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-06-07
Last Modified:2022-11-09
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