150294 - Generation and characterisation of four multiple sclerosis iPSC lines from a single family.pdf (3.15 MB)
Generation and characterisation of four multiple sclerosis iPSC lines from a single family
journal contribution
posted on 2023-05-21, 08:08 authored by Alastair FortuneAlastair Fortune, Bruce TaylorBruce Taylor, Jac CharlesworthJac Charlesworth, Kathryn BurdonKathryn Burdon, Nicholas BlackburnNicholas Blackburn, Jessica FletcherJessica Fletcher, Ashish Mehta, Kaylene YoungKaylene YoungMultiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account for ∼48% of MS risk (International Multiple Sclerosis Genetics Consortium, 2019). Despite this, families with a high incidence of MS are rare. We have generated four induced pluripotent stem cell (iPSC) lines from individuals with relapsing-remitting and secondary progressive MS within a single family. The generation of disease-specific iPSC lines from multiple members of a single family will facilitate MS genetic and functional studies.
Funding
Medical Research Future Fund
History
Publication title
Stem Cell ResearchVolume
62Article number
102828Number
102828Pagination
1-4ISSN
1873-5061Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier BVPlace of publication
NetherlandsRights statement
© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license, https://creativecommons.org/licenses/by-nc-nd/4.0/Repository Status
- Open