eCite Digital Repository

New horizonsóCognitive dysfunction associated with type 2 diabetes


Moran, C and Than, S and Callisaya, M and Beare, R and Srikanth, V, New horizons Cognitive dysfunction associated with type 2 diabetes, Journal of Clinical Endocrinology and Metabolism, 107, (4) pp. 929-942. ISSN 0021-972X (2022) [Substantial Review]

Pending copyright assessment - Request a copy

DOI: doi:10.1210/clinem/dgab797


The prevalence of type 2 diabetes (T2D) and cognitive dysfunction increases with age. As society ages, clinicians will be increasingly tasked with managing older people who have both T2D and cognitive dysfunction. T2D is associated with an increased risk of cognitive dysfunction and hence there is increasing interest in whether T2D is a causal factor in the pathogenesis of cognitive decline and dementia. Recent advances in the use of sensitive measures of in vivo brain dysfunction in life-course studies can help understand potential mechanistic pathways and also help guide recommendations for clinical practice.

In this article we will describe new horizons in the understanding of cognitive dysfunction associated with T2D. Coming from a clinical perspective, we discuss potential mechanisms and pathways linking the 2 conditions and the contribution of multimodal neuroimaging and study designs to advancing understanding in the field. We also highlight the important issues on the horizon that will need addressing in clinical identification, management, and risk reduction for people with coexistent T2D and cognitive dysfunction.

Item Details

Item Type:Substantial Review
Keywords:type 2 diabetes, cognitive dysfunction, diabetes, dementia
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Geriatrics and gerontology
Objective Division:Health
Objective Group:Provision of health and support services
Objective Field:Primary care
UTAS Author:Callisaya, M (Dr Michele Callisaya)
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:150255
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-06-05
Last Modified:2022-06-06

Repository Staff Only: item control page