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The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus


Gurung, RL and Fitzgerald, LM and Liu, E and McComish, BJ and Kaidonis, G and Ridge, B and Hewitt, AW and Vote, BJT and Verma, N and Craig, JE and Burdon, KP, The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus, BMC Ophthalmology, 22, (1) Article 94. ISSN 1471-2415 (2022) [Refereed Article]

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© 2022. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.1186/s12886-022-02325-x



To assess whether insulin therapy impacts the effectiveness of anti-vascular endothelial growth factor (anti-VEGF) injection for the treatment of diabetic macular edema (DME) in type 2 diabetes mellitus.


This was a retrospective multi-center analysis. The best-corrected visual acuity (BCVA) at 12 months, BCVA change, central macular thickness (CMT), CMT change, and cumulative injection number were compared between the insulin and the oral hypoglycemic agent (OHA) groups.


The mean final BCVA and CMT improved in both the insulin (N = 137; p < 0.001; p < 0.001, respectively) and the OHA group (N = 61; p = 0.199; p < 0.001, respectively). The two treatment groups were comparable for final BCVA (p = 0.263), BCVA change (p = 0.184), final CMT (p = 0.741), CMT change (p = 0.458), and the cumulative injections received (p = 0.594). The results were comparable between the two groups when stratified by baseline vision (p > 0.05) and baseline HbA1c (p > 0.05).


Insulin therapy does not alter treatment outcomes for anti-VEGF therapy in DME.

Item Details

Item Type:Refereed Article
Keywords:diabetic macular edema, anti-VEGF, insulin, visual acuity, central macular thickness, diabetic retinopathy, treatment outcomes
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Gurung, RL (Dr Rajya Gurung)
UTAS Author:Fitzgerald, LM (Dr Liesel FitzGerald)
UTAS Author:McComish, BJ (Dr Bennet McComish)
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Vote, BJT (Dr Brendan Vote)
UTAS Author:Verma, N (Dr Nitin Verma)
UTAS Author:Burdon, KP (Professor Kathryn Burdon)
ID Code:150210
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-06-02
Last Modified:2022-09-29
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