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The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus
Citation
Gurung, RL and Fitzgerald, LM and Liu, E and McComish, BJ and Kaidonis, G and Ridge, B and Hewitt, AW and Vote, BJT and Verma, N and Craig, JE and Burdon, KP, The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus, BMC Ophthalmology, 22, (1) Article 94. ISSN 1471-2415 (2022) [Refereed Article]
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Copyright Statement
© 2022. The Authors. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
DOI: doi:10.1186/s12886-022-02325-x
Abstract
Objectives
To assess whether insulin therapy impacts the effectiveness of anti-vascular endothelial growth factor (anti-VEGF) injection for the treatment of diabetic macular edema (DME) in type 2 diabetes mellitus.
Methods
This was a retrospective multi-center analysis. The best-corrected visual acuity (BCVA) at 12 months, BCVA change, central macular thickness (CMT), CMT change, and cumulative injection number were compared between the insulin and the oral hypoglycemic agent (OHA) groups.
Results
The mean final BCVA and CMT improved in both the insulin (N = 137; p < 0.001; p < 0.001, respectively) and the OHA group (N = 61; p = 0.199; p < 0.001, respectively). The two treatment groups were comparable for final BCVA (p = 0.263), BCVA change (p = 0.184), final CMT (p = 0.741), CMT change (p = 0.458), and the cumulative injections received (p = 0.594). The results were comparable between the two groups when stratified by baseline vision (p > 0.05) and baseline HbA1c (p > 0.05).
Conclusion
Insulin therapy does not alter treatment outcomes for anti-VEGF therapy in DME.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | diabetic macular edema, anti-VEGF, insulin, visual acuity, central macular thickness, diabetic retinopathy, treatment outcomes |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Ophthalmology and optometry |
| Research Field: | Ophthalmology |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the biomedical and clinical sciences |
| UTAS Author: | Gurung, RL (Dr Rajya Gurung) |
| UTAS Author: | Fitzgerald, LM (Dr Liesel FitzGerald) |
| UTAS Author: | McComish, BJ (Dr Bennet McComish) |
| UTAS Author: | Hewitt, AW (Professor Alex Hewitt) |
| UTAS Author: | Vote, BJT (Dr Brendan Vote) |
| UTAS Author: | Verma, N (Dr Nitin Verma) |
| UTAS Author: | Burdon, KP (Professor Kathryn Burdon) |
| ID Code: | 150210 |
| Year Published: | 2022 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2022-06-02 |
| Last Modified: | 2022-09-29 |
| Downloads: | 5 View Download Statistics |
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