150186 - Using MS induced pluripotent stem cells to investigate MS aetiology.pdf (853.41 kB)
Using MS induced pluripotent stem cells to investigate MS aetiology
journal contribution
posted on 2023-05-21, 07:52 authored by Alastair FortuneAlastair Fortune, Jessica FletcherJessica Fletcher, Nicholas BlackburnNicholas Blackburn, Kaylene YoungKaylene YoungMultiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of immune and central nervous system cell types. Despite extensive investigation into the aetiology of MS, the underlying cause/s remain elusive and consequently, faithful in vitro or in vivo preclinical models of MS do not exist. Advances in human stem cell technologies have enabled the generation of induced pluripotent stem cells (iPSCs) from people with MS. This review summarises the discoveries made using iPSCs derived from people with MS and explores their current and potential application/s in MS research.
Funding
Medical Research Future Fund
History
Publication title
Multiple Sclerosis and Related DisordersVolume
63Pagination
103839ISSN
2211-0348Department/School
Menzies Institute for Medical ResearchPublisher
Elsevier BVPlace of publication
NetherlandsRights statement
Copyright 2022 The Author(s) Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/Repository Status
- Open