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Using MS induced pluripotent stem cells to investigate MS aetiology


Fortune, AJ and Fletcher, JL and Blackburn, NB and Young, KM, Using MS induced pluripotent stem cells to investigate MS aetiology, Multiple Sclerosis and Related Disorders, 63 pp. 103839. ISSN 2211-0348 (2022) [Refereed Article]


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Copyright 2022 The Author(s) Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

DOI: doi:10.1016/j.msard.2022.103839


Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of immune and central nervous system cell types. Despite extensive investigation into the aetiology of MS, the underlying cause/s remain elusive and consequently, faithful in vitro or in vivo preclinical models of MS do not exist. Advances in human stem cell technologies have enabled the generation of induced pluripotent stem cells (iPSCs) from people with MS. This review summarises the discoveries made using iPSCs derived from people with MS and explores their current and potential application/s in MS research.

Item Details

Item Type:Refereed Article
Keywords:Multiple Sclerosis (MS), induced Pluripotent Stem Cells (iPSCs), oligodendrocytes, neurons, microglia, disease modelling, stem cells
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Fortune, AJ (Mr Alastair Fortune)
UTAS Author:Fletcher, JL (Dr Jessica Fletcher)
UTAS Author:Blackburn, NB (Dr Nicholas Blackburn)
UTAS Author:Young, KM (Professor Kaylene Young)
ID Code:150186
Year Published:2022
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-06-01
Last Modified:2022-10-03
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