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Actual drug-related harms in residential aged care facilities: a narrative review


Ali, S and Curtain, C and Bereznicki, LRE and Salahudeen, MS, Actual drug-related harms in residential aged care facilities: a narrative review, Expert Opinion on Drug Safety, 21, (8) pp. 1047-1060. ISSN 1474-0338 (2022) [Refereed Article]

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Copyright 2022 Informa UK Limited, trading as Taylor & Francis Group

DOI: doi:10.1080/14740338.2022.2084071


Introduction: Older people in residential aged care facilities (RACFs) have a high risk of safety issues and concerns about the potential quality of care received. This narrative review investigates the types of actual drug-related harms, their prevalence, reporting of any standard definitions for these harms, and their identification methods.

Areas covered: The authors conducted a systematic search on Ovid Embase, Ovid Medline, and PubMed from March 2001 to March 2021. This narrative review included all types of studies targeting aged care residents aged 65 years and above with actual drug-related harms.

Expert opinion: The prevalence of actual drug-related harms in residents ranged from 0.07% to 63.0%. Falls, drug-drug interactions, neuropsychiatric symptoms, anaphylaxis, urinary tract infection, hypoglycemia, hypokalaemia, and acute kidney injury are the most common drug-related harms in older residents. Psychotropic drugs are the most common drug class implicated in these harms. Evidence related to the association between individual psychotropic drugs and injury, or harm is also lacking. Due to the variation in study duration, reported prevalence, identification methods, and absence of a definition for actual drug-related harms in most studies, further research is mandated to understand the prevalence and clinical implications of drug-related harms in older residents.

Item Details

Item Type:Refereed Article
Keywords:harms, ADEs, older people, RACFs, drug-related harm, medication-related harm
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health outcomes
UTAS Author:Ali, S (Mr Sheraz Ali)
UTAS Author:Curtain, C (Mr Colin Curtain)
UTAS Author:Bereznicki, LRE (Professor Luke Bereznicki)
UTAS Author:Salahudeen, MS (Dr Mohammed Salahudeen)
ID Code:150164
Year Published:2022
Deposited By:Pharmacy
Deposited On:2022-05-30
Last Modified:2022-10-12

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