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A rare alder-ene cycloisomerization of 1,6-allenynes
journal contribution
posted on 2023-05-21, 07:40 authored by Joyce, LM, Drew, MA, Tague, AJ, Thaima, T, Gouranourimi, A, Alireza AriafardAlireza Ariafard, Pyne, SG, Hyland, CJTThermally induced cycloisomerization reactions of 1,6-allenynes gives α-methylene-γ-lactams via intramolecular Alder-ene reactions. The mechanism is supported by computational and deuterium labelling studies. This thermal, non-radical method enables the discovery of a hitherto unknown route that proceeds via a divergent mechanism distinct from the previous [2+2] cycloisomerization manifold.
History
Publication title
Chemistry - A European JournalVolume
28Issue
12Article number
e202104022Number
e202104022Pagination
1-5ISSN
0947-6539Department/School
School of Natural SciencesPublisher
Wiley-V C H Verlag GmbhPlace of publication
Po Box 10 11 61, Weinheim, Germany, D-69451Rights statement
© 2021 Wiley-VCH GmbHRepository Status
- Restricted