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Investigating the feasibility and ethical implications of phenotypic screening using stem cell - derived tissue models to detect and manage disease

Citation

Harris, AR and Walker, MJ and Gilbert, F and McGivern, P, Investigating the feasibility and ethical implications of phenotypic screening using stem cell - derived tissue models to detect and manage disease, Stem Cell Reports, 17, (1) pp. 1-10. ISSN 2213-6711 (2022) [Refereed Article]


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DOI: doi:10.1016/j.stemcr.2022.04.002

Abstract

Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient displays symptoms, allowing for their use as a disease screening tool. This raises numerous issues, some of which can be addressed using similar approaches from genetic screenings, while others are unique. One issue is the relationship between disease disposition, biomarker detection, and patient symptoms and how tissue models could be used to define disease. Other issues include decisions of when to screen, what diseases to screen for, and what treatment options should be offered.

Item Details

Item Type:Refereed Article
Keywords:ethics, stem cells, phenotypic screening,
Research Division:Philosophy and Religious Studies
Research Group:Applied ethics
Research Field:Bioethics
Objective Division:Culture and Society
Objective Group:Ethics
Objective Field:Bioethics
UTAS Author:Gilbert, F (Associate Professor Frederic Gilbert)
ID Code:149969
Year Published:2022
Web of Science® Times Cited:1
Deposited By:Philosophy and Gender Studies
Deposited On:2022-05-04
Last Modified:2022-05-04
Downloads:0

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