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Comparing the renal outcomes in patients with atrial fibrillation receiving different oral anticoagulants
Citation
Bezabhe, WM and Bereznicki, LR and Radford, J and Wimmer, BC and Salahudeen, MS and Bindoff, I and Peterson, GM, Comparing the renal outcomes in patients with atrial fibrillation receiving different oral anticoagulants, Expert Review of Clinical Pharmacology pp. 1-6. ISSN 1751-2433 (2022) [Refereed Article]
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DOI: doi:10.1080/17512433.2022.2070151
Abstract
Compared with warfarin, prescribing of direct-acting oral anticoagulants (DOACs) was associated with a lower risk of renal function decline per 1000 person-years: hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.68-0.81, p < 0.001 for ≥30% decline in eGFR; HR 0.28, 95% CI 0.20-0.41, p < 0.001 for eGFR decline to ≤30 mL/min/1.73 m2; and HR 0.45, 95% CI 0.35-0.58, p < 0.001 for serum creatinine doubling. Compared with dabigatran, rivaroxaban use had a significantly lowered risk of decline in eGFR to ≤30 mL/min/1.73 m2 (HR 0.29, 95% CI 0.13-0.66, p = 0.003) and risk of doubling of serum creatinine (HR 0.62, 95% CI 0.40-0.95, p = 0.030).
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | estimated glomerular filtration rate, oral anticoagulant, renal function decline, dabigatran, apixaban, rivaroxaban, warfarin |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Clinical pharmacology and therapeutics |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Diagnosis of human diseases and conditions |
| UTAS Author: | Bezabhe, WM (Dr Woldesellassie Bezabhe) |
| UTAS Author: | Bereznicki, LR (Professor Luke Bereznicki) |
| UTAS Author: | Radford, J (Professor Jan Radford) |
| UTAS Author: | Wimmer, BC (Dr Barbara Wimmer) |
| UTAS Author: | Salahudeen, MS (Dr Mohammed Salahudeen) |
| UTAS Author: | Bindoff, I (Dr Ivan Bindoff) |
| UTAS Author: | Peterson, GM (Professor Gregory Peterson) |
| ID Code: | 149921 |
| Year Published: | 2022 |
| Deposited By: | Pharmacy |
| Deposited On: | 2022-04-28 |
| Last Modified: | 2022-05-18 |
| Downloads: | 0 |
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