Compared with warfarin, prescribing of direct-acting oral anticoagulants (DOACs) was associated with a lower risk of renal function decline per 1000 person-years: hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.68-0.81, p < 0.001 for ≥30% decline in eGFR; HR 0.28, 95% CI 0.20-0.41, p < 0.001 for eGFR decline to ≤30 mL/min/1.73 m2; and HR 0.45, 95% CI 0.35-0.58, p < 0.001 for serum creatinine doubling. Compared with dabigatran, rivaroxaban use had a significantly lowered risk of decline in eGFR to ≤30 mL/min/1.73 m2 (HR 0.29, 95% CI 0.13-0.66, p = 0.003) and risk of doubling of serum creatinine (HR 0.62, 95% CI 0.40-0.95, p = 0.030).

Item Type:	Refereed Article
Keywords:	estimated glomerular filtration rate, oral anticoagulant, renal function decline, dabigatran, apixaban, rivaroxaban, warfarin
Research Division:	Biomedical and Clinical Sciences
Research Group:	Pharmacology and pharmaceutical sciences
Research Field:	Clinical pharmacology and therapeutics
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Diagnosis of human diseases and conditions
UTAS Author:	Bezabhe, WM (Dr Woldesellassie Bezabhe)
UTAS Author:	Bereznicki, LR (Professor Luke Bereznicki)
UTAS Author:	Radford, J (Professor Jan Radford)
UTAS Author:	Wimmer, BC (Dr Barbara Wimmer)
UTAS Author:	Salahudeen, MS (Dr Mohammed Salahudeen)
UTAS Author:	Bindoff, I (Dr Ivan Bindoff)
UTAS Author:	Peterson, GM (Professor Gregory Peterson)
ID Code:	149921
Year Published:	2022
Deposited By:	Pharmacy
Deposited On:	2022-04-28
Last Modified:	2022-10-26
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