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Does aspirin prevent incident heart failure in healthy older adults? Examining the evidence from the ASPREE trial

Citation

Zhou, Z and Nelson, M and Ernst, ME and Reid, C and McNeil, J and Tonkin, A, ASPREE Investigator Group, Does aspirin prevent incident heart failure in healthy older adults? Examining the evidence from the ASPREE trial, Circulation: Heart Failure ISSN 1941-3289 (2022) [Refereed Article]

Copyright Statement

Copyright 2022 American Heart Association, Inc.

Official URL: https://www.ahajournals.org/doi/abs/10.1161/CIRCHE...

Abstract

Heart failure (HF) is now the leading cause of a first major cardiovascular event and the most common hospital discharge diagnosis in older adults. A recent cohort study by Mujaj et al included 30 000 individuals at risk for HF (mean age, 67 years), of whom 26% had a history of coronary artery disease. The analysis demonstrated an increased risk of HF in those taking aspirin (adjusted hazard ratio [HR], 1.26 [95% CI, 1.121.41]) but highlighted the need for evidence from randomized trials.2 ASPREE (Aspirin in Reducing Events in the Elderly (URL: https://www.clinicaltrials.gov; Unique identifier: NCT01038583) was a double-blinded, randomized, placebo-controlled trial of aspirin in healthy older subjects.

Item Details

Item Type:Refereed Article
Keywords:aspirin, heart failure, elderly, primary prevention
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Efficacy of medications
UTAS Author:Zhou, Z (Dr Zhen Zhou)
UTAS Author:Nelson, M (Professor Mark Nelson)
ID Code:149825
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-04-14
Last Modified:2022-05-13
Downloads:0

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