Heart failure (HF) is now the leading cause of a first major cardiovascular event and the most common hospital discharge diagnosis in older adults. A recent cohort study by Mujaj et al included 30 000 individuals at risk for HF (mean age, 67 years), of whom 26% had a history of coronary artery disease. The analysis demonstrated an increased risk of HF in those taking aspirin (adjusted hazard ratio [HR], 1.26 [95% CI, 1.12–1.41]) but highlighted the need for evidence from randomized trials.2 ASPREE (Aspirin in Reducing Events in the Elderly (URL: https://www.clinicaltrials.gov; Unique identifier: NCT01038583) was a double-blinded, randomized, placebo-controlled trial of aspirin in healthy older subjects.

Item Type:	Refereed Article
Keywords:	aspirin, heart failure, elderly, primary prevention
Research Division:	Biomedical and Clinical Sciences
Research Group:	Cardiovascular medicine and haematology
Research Field:	Cardiology (incl. cardiovascular diseases)
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Efficacy of medications
UTAS Author:	Zhou, Z (Dr Zhen Zhou)
UTAS Author:	Nelson, M (Professor Mark Nelson)
ID Code:	149825
Year Published:	2022
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2022-04-14
Last Modified:	2022-10-07
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