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Longitudinal association of infrapatellar fat pad signal intensity alteration with biochemical biomarkers in knee osteoarthritis


Cen, H and Yan, Q and Han, W and Meng, T and Chen, Z and Ruan, G and Wang, T and Pan, F and Chen, D and Kraus, VB and Hunter, DJ and Ding, C, Longitudinal association of infrapatellar fat pad signal intensity alteration with biochemical biomarkers in knee osteoarthritis, Rheumatology Article keac214. ISSN 1462-0324 (2022) [Refereed Article]

Copyright Statement

The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.

DOI: doi:10.1093/rheumatology/keac214



To explore the longitudinal association of quantitative infrapatellar fat pad (IPFP) signal intensity alteration with osteoarthritis (OA)-related biomarkers.


Eighteen OA-related biochemical biomarkers of 600 knee OA participants in the Foundation for the National Institutes of Health OA Biomarkers Consortium (FNIH) study were extracted. The quantitative IPFP signal intensity measures was acquired based on magnetic resonance imaging, including mean value [Mean (IPFP)] and standard deviation [sDev (IPFP)] of the whole IPFP, median value [Median (H)] and upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity to volume of whole IPFP [Percentage (H)] and Clustering factor (H). The linear mixed-effect model was applied to determine the longitudinal associations between IPFP signal intensity alteration and biochemical biomarkers over 2 years.


All IPFP measures except for Clustering factor (H) were positively associated with urine collagenase-cleaved type II collagen neoepitope (uC2C), urine C-terminal cross-linked telopeptide of type II collagen (uCTX-II), urine C-terminal cross-linked telopeptide of type I collagen-α (uCTX-Iα) and urine N-terminal cross-linked telopeptide of type I collagen (uNTX-I). Mean (IPFP), Median (H) and Percentage (H) were positively associated with nitrated form of an epitope located in the triple helix of type II collagen (Coll2-1 NO2). Mean (IPFP), Median (H) and UQ (H) were positively associated with sCTX-I and uCTX-Iβ. Positive associations between sDev (IPFP), Percentage (H) and serum hyaluronic acid (sHA) were found.


Our results suggest a role of IPFP signal intensity alteration in joint tissue remodelling on a molecular level.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, infra-patellar fat pad, magnetic resonance imaging, FNIH, biomarker
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Cen, H (Dr Han Cen)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Chen, Z (Dr Zhongshan Chen)
UTAS Author:Ruan, G (Mr Guangfeng Ruan)
UTAS Author:Wang, T (Dr Tian Wang)
UTAS Author:Pan, F (Dr Feng Pan)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:149787
Year Published:2022
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-04-12
Last Modified:2022-11-08

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