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Island Study Linking Aging and Neurodegenerative Disease (ISLAND) targeting dementia risk reduction: protocol for a prospective web-based cohort study


Bartlett, L and Doherty, K and Farrow, M and Kim, S and Hill, E and King, A and Alty, J and Eccleston, C and Kitsos, A and Bindoff, A and Vickers, JC, Island Study Linking Aging and Neurodegenerative Disease (ISLAND) targeting dementia risk reduction: protocol for a prospective web-based cohort study, JMIR Research Protocols, 11, (3) Article e34688. ISSN 1929-0748 (2022) [Refereed Article]

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Copyright Statement

©Larissa Bartlett, Kathleen Doherty, Maree Farrow, Sarang Kim, Edward Hill, Anna King, Jane Alty, Claire Eccleston, Alex Kitsos, Aidan Bindoff, James C Vickers. Originally published in JMIR Research Protocols (, 01.03.2022. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited.

DOI: doi:10.2196/34688


Background: Up to 40% of incident dementia is considered attributable to behavioral and lifestyle factors. Given the current lack of medical treatments and the projected increase in dementia prevalence, a focus on prevention through risk reduction is needed.

Objective: We aim to increase dementia risk knowledge and promote changes in dementia risk behaviors at individual and population levels.

Methods: The Island Study Linking Aging and Neurodegenerative Disease (ISLAND) is a long-term prospective, web-based cohort study with nested interventions that will be conducted over a 10-year period. Target participants (n=10,000) reside in Tasmania and are aged 50 years or over. Survey data on knowledge, attitudes, and behaviors related to modifiable dementia risk factors will be collected annually. After each survey wave, participants will be provided with a personalized dementia risk profile containing guidelines for reducing risk across 9 behavioral and lifestyle domains and with opportunities to engage in educational and behavioral interventions targeting risk reduction. Survey data will be modeled longitudinally with intervention engagement indices, cognitive function indices, and blood-based biomarkers, to measure change in risk over time.

Results: In the initial 12 months (October 2019 to October 2020), 6410 participants have provided baseline data. The study is ongoing.

Conclusions: Recruitment targets are feasible and efforts are ongoing to achieve a representative sample. Findings will inform future public health dementia risk reduction initiatives by showing whether, when, and how dementia risk can be lowered through educational and behavioral interventions, delivered in an uncontrolled real-world context.

Item Details

Item Type:Refereed Article
Keywords:health behaviours, self-efficacy, public health, online, prospective research cohort, dementia, aging, older adult, neurodegenerative, modifiable risk factors, risk reduction, prevention, lifestyle and behaviors, lifestyle, behavior change, intervent
Research Division:Health Sciences
Research Group:Public health
Research Field:Health promotion
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Preventive medicine
UTAS Author:Bartlett, L (Mrs Larissa Bartlett)
UTAS Author:Doherty, K (Dr Kathleen Doherty)
UTAS Author:Farrow, M (Dr Maree Farrow)
UTAS Author:Kim, S (Dr Sarang Kim)
UTAS Author:Hill, E (Dr Eddy Roccati)
UTAS Author:King, A (Professor Anna King)
UTAS Author:Alty, J (Associate Professor Jane Alty)
UTAS Author:Eccleston, C (Dr Claire Eccleston)
UTAS Author:Kitsos, A (Rev Alex Kitsos)
UTAS Author:Bindoff, A (Mr Aidan Bindoff)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:149782
Year Published:2022
Web of Science® Times Cited:3
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2022-04-12
Last Modified:2022-11-08
Downloads:6 View Download Statistics

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