eCite Digital Repository

Frequent cross-species transmissions of foamy virus between domestic and wild felids

Citation

Kraberger, S and Fountain-Jones, NM and Gagne, RB and Malmberg, J and Dannemiller, NG and Logan, K and Alldredge, M and Varsani, A and Crooks, KR and Craft, M and Carver, S and Vandewoude, S, Frequent cross-species transmissions of foamy virus between domestic and wild felids, Virus Evolution, 6, (1) pp. 1-13. ISSN 2057-1577 (2020) [Refereed Article]


Preview
PDF (Published version)
3Mb
  

Copyright Statement

Copyright The Author(s) 2020. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: doi:10.1093/ve/vez058

Abstract

Emerging viral outbreaks resulting from host switching is an area of continued scientific interest. Such events can result in disease epidemics or in some cases, clinically silent outcomes. These occurrences are likely relatively common and can serve as tools to better understand disease dynamics, and may result in changes in behavior, fecundity, and, ultimately survival of the host. Feline foamy virus (FFV) is a common retrovirus infecting domestic cats globally, which has also been documented in the North American puma (Puma concolor). The prevalent nature of FFV in domestic cats and its ability to infect wild felids, including puma, provides an ideal system to study cross-species transmission across trophic levels (positions in the food chain), and evolution of pathogens transmitted between individuals following direct contact. Here we present findings from an extensive molecular analysis of FFV in pumas, focused on two locations in Colorado, and in relation to FFV recovered from domestic cats in this and previous studies. Prevalence of FFV in puma was high across the two regions, ∼77 per cent (urban interface site) and ∼48 per cent (rural site). Comparison of FFV from pumas living across three states; Colorado, Florida, and California, indicates FFV is widely distributed across North America. FFV isolated from domestic cats and pumas was not distinguishable at the host level, with FFV sequences sharing >93 per cent nucleotide similarity. Phylogenetic, Bayesian, and recombination analyses of FFV across the two species supports frequent cross-species spillover from domestic cat to puma during the last century, as well as frequent puma-to-puma intraspecific transmission in Colorado, USA. Two FFV variants, distinguished by significant difference in the surface unit of the envelope protein, were commonly found in both hosts. This trait is also shared by simian foamy virus and may represent variation in cell tropism or a unique immune evasion mechanism. This study elucidates evolutionary and cross-species transmission dynamics of a highly prevalent multi-host adapted virus, a system which can further be applied to model spillover and transmission of pathogenic viruses resulting in widespread infection in the new host.

Item Details

Item Type:Refereed Article
Keywords:Epidemiology
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Veterinary sciences
Research Field:Veterinary parasitology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Control of pests, diseases and exotic species in terrestrial environments
UTAS Author:Fountain-Jones, NM (Dr Nicholas Fountain-Jones)
UTAS Author:Carver, S (Dr Scott Carver)
ID Code:149650
Year Published:2020
Web of Science® Times Cited:11
Deposited By:Zoology
Deposited On:2022-04-05
Last Modified:2022-05-13
Downloads:4 View Download Statistics

Repository Staff Only: item control page