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Navigating to the most promising directions amid complex fields of vaccine development: a chlamydial case study

Citation

Lizarraga, D and Carver, S and Timms, P, Navigating to the most promising directions amid complex fields of vaccine development: a chlamydial case study, Expert Review of Vaccines, 18, (12) pp. 1323-1337. ISSN 1476-0584 (2019) [Refereed Article]

Copyright Statement

Copyright 2019 Informa UK Limited, trading as Taylor & Francis Group

DOI: doi:10.1080/14760584.2019.1698954

Abstract

Background: Vaccine-development research is proliferating making it difficult to determine the most promising vaccine candidates. Exemplary of this problem is vaccine development against Chlamydia, a pathogen of global public health and financial importance.

Methods: We systematically extracted data from studies that included chlamydial load or host immune parameter measurements, estimating 4,453 standardized effect sizes between control and chlamydial immunization experimental groups.

Results: Chlamydial immunization studies most often used (78%) laboratory mouse models. Depending on chlamydial species, single and multiple recombinant protein, viral and bacterial vectors, dendritic transfer, and dead whole pathogen were most effective at reducing chlamydial load. Immunization-driven decrease in chlamydial load was associated with increases in IFNg, IgA, IgG1, and IgG2a. Using data from individual studies, the magnitude of IgA and IgG2a increase was correlated with chlamydial load reduction. IFNg also showed this pattern for C. trachomatis, but not for C. muridarum. We also reveal the chlamydial vaccine development field to be highly bias toward studies showing these effects, limiting lessons learned from negative results.

Conclusions: Most murine immunizations against Chlamydia reduced chlamydial load and increased host immune parameters. These methods are novel for vaccine development and are critical in identifying trends where large quantities of literature exist.

Item Details

Item Type:Refereed Article
Keywords:Epidemiology
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Veterinary sciences
Research Field:Veterinary parasitology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Control of pests, diseases and exotic species in terrestrial environments
UTAS Author:Lizarraga, D (Mr David Lizarraga)
UTAS Author:Carver, S (Dr Scott Carver)
ID Code:149649
Year Published:2019
Funding Support:Australian Research Council (LP160100138)
Web of Science® Times Cited:7
Deposited By:Zoology
Deposited On:2022-04-05
Last Modified:2022-05-05
Downloads:0

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