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Variation in intra-individual lentiviral evolution rates: a systematic review of human, nonhuman primate, and felid species

Citation

Krakoff, E and Gagne, RB and VandeWoude, S and Carver, S, Variation in intra-individual lentiviral evolution rates: a systematic review of human, nonhuman primate, and felid species, Journal of Virology, 93, (16) Article e00538-19. ISSN 1098-5514 (2019) [Refereed Article]


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Copyright Statement

Copyright 2019 American Society of Microbiology

DOI: doi:10.1128/JVI.00538-19

Abstract

Lentiviral replication mediated by reverse transcriptase is considered to be highly error prone, leading to a high intra-individual evolution rate that promotes evasion of neutralization and persistent infection. Understanding lentiviral intra-individual evolutionary dynamics on a comparative basis can therefore inform research strategies to aid in studies of pathogenesis, vaccine design, and therapeutic intervention. We conducted a systematic review of intra-individual evolution rates for three species groups of lentiviruses—feline immunodeficiency virus (FIV), simian immunodeficiency virus (SIV), and human immunodeficiency virus (HIV). Overall, intra-individual rate estimates differed by virus but not by host, gene, or viral strain. Lentiviral infections in spillover (nonadapted) hosts approximated infections in primary (adapted) hosts. Our review consistently documents that FIV evolution rates within individuals are significantly lower than the rates recorded for HIV and SIV. FIV intra-individual evolution rates were noted to be equivalent to FIV interindividual rates. These findings document inherent differences in the evolution of FIV relative to that of primate lentiviruses, which may signal intrinsic difference of reverse transcriptase between these viral species or different host-viral interactions. Analysis of lentiviral evolutionary selection pressures at the individual versus population level is valuable for understanding transmission dynamics and the emergence of virulent and avirulent strains and provides novel insight for approaches to interrupt lentiviral infections.

Item Details

Item Type:Refereed Article
Keywords:evolution rate, feline immunodeficiency virus, human immunodeficiency virus, lentivirus, simian immunodeficiency virus, epidemiology
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Veterinary sciences
Research Field:Veterinary parasitology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Control of pests, diseases and exotic species in terrestrial environments
UTAS Author:Carver, S (Dr Scott Carver)
ID Code:149636
Year Published:2019
Web of Science® Times Cited:9
Deposited By:Zoology
Deposited On:2022-04-05
Last Modified:2022-05-24
Downloads:2 View Download Statistics

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