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Associations between clinical canine leishmaniosis and multiple vector-borne co-infections: a case-control serological study

Citation

Attipa, C and Solano-Gallego, L and Leutenegger, CM and Papasouliotis, K and Soutter, F and Balzer, J and Carver, S and Buch, JS and Tasker, S, Associations between clinical canine leishmaniosis and multiple vector-borne co-infections: a case-control serological study, BMC Veterinary Research, 15 Article 331. ISSN 1746-6148 (2019) [Refereed Article]


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Copyright Statement

Copyright 2019 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/s12917-019-2083-6

Abstract

Background

Dogs that have clinical leishmaniosis (ClinL), caused by the parasite Leishmania infantum, are commonly co-infected with other pathogens, especially vector-borne pathogens (VBP). A recent PCR-based study found that ClinL dogs are more likely to be additionally infected with the rickettsial bacteria Ehrlichia canis. Further information on co-infections in ClinL cases with VBP, as assessed by serology, is required. The research described in this report determined if dogs with ClinL are at higher risk of exposure to VBP than healthy control dogs using a case-control serology study.

Results

Of the 47 dogs with ClinL, anti-E. canis/ Ehrlichia ewingii antibodies were detected in 17 (36.2%), anti-Anaplasma phagocytophilum/Anaplasma platys antibodies in 5 (10.6%) and antigen for Dirofilaria immitis in 2 (4.3%). Of the 87 control dogs, anti-E. canis/E. ewingii antibodies were detected in 14 (16.1%) and anti-A. phagocytophilum/A. platys antibodies in 2 (2.3%). No anti-Borrelia burgdorferi antibody tests were positive. No statistical differences between the ClinL dogs and control dogs regarding lifestyle or use of ectoparasitic prevention, were identified. The ClinL was significantly associated with anti-E. canis/E. ewingii antibodies (odds ratio = 2.9, 95% confidence interval: 1.36.7, P = 0.010) compared to controls by both multivariable logistic regression and structural equation modelling.

Conclusions

It was demonstrated that an increased risk for E. canis/E. ewingii seropositivity is present in dogs with ClinL compared to clinically healthy control dogs, despite similar ectoparasitic prevention use and lifestyle. Based on these findings it is suggested that dogs with ClinL should not only be tested for E. canis co-infection using PCR but also serologically for E. canis/E. ewingii.

Item Details

Item Type:Refereed Article
Keywords:epidemiology, dog, Leishmania infantum, Ehrlichia canis, Borrelia burgdorferi, Acanthocheilonema reconditum, vectorborne pathogen, co-infection, Cyprus
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Veterinary sciences
Research Field:Veterinary parasitology
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Control of pests, diseases and exotic species in terrestrial environments
UTAS Author:Carver, S (Dr Scott Carver)
ID Code:149606
Year Published:2019
Web of Science® Times Cited:5
Deposited By:Zoology
Deposited On:2022-04-05
Last Modified:2022-05-13
Downloads:2 View Download Statistics

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